Introduction: Synaptic plasticity has been suggested as the primary physiological mechanism underlying memory formation. Many experimental approaches have been used to investigate whether the mechanisms underlying long-term potentiation (LTP) are activated during learning. Nevertheless, little evidence states that hippocampal-dependent learning triggers synaptic plasticity. In this study, we in...

Introduction: The N-methyl-D-aspartate (NMDA) receptors, which have been implicated in memory formation, could be noncompetitively blocked by ketamine. The present study examines the short term effect of ketamine on induction of anterograde and retrograde amnesia in male rats using Morris water maze (MWM). Methods: Male N-MRI rats were randomly divided into nine experimental groups. MWM stud...

it is important for people to improve cognitive and motor performance. the purpouse of this study was to investigate the effect of running on treadmill in spatial memory and learning and motor performance. 24 albino-wistar healthy male rats were randomly divided into control and activity groups. activity group ran 7 days on treadmill (speed 22m/min 30 minutes a day). after the end of activity p...

Introduction: The cholinergic system plays an important role in learning and memory. Administration of either extracts of Crocus Sativus (Saffron) or its constituent, crocin, reduced ethanol-induced memory impairment. Based on the above findings, we investigated the effect of crocin in antagonizing spatial learning and memory impairment induced by scopolamine, a cholinergic receptor antagoni...

introduction: patients with epilepsy can have impaired cognitive abilities. many factors contribute to this impairment, including the adverse effects of antiepileptic drugs like gabapentin (gbp). apart from anti-epilectic action, gabapentin is used to relieve ethanol withdrawal syndrome. because both gbp and ethanol act on gaba ergic system, the purpose of this study was to evaluate their effec...

introduction: a large body of evidence points to oxidative stress as prime candidate mediating the behavioral impairments and memory deficits in alzheimer's disease (ad). it has been demonstrated that hyperoxia preconditioning activates complex endogenous neuroprotective mechanisms including an increase in capacity of antioxidant defence mechanisms. the aim of this study was to investigate...

background: testosterone and its metabolites have important roles in learning and memory. the current study has conducted to assess the effect of pre-training, post-training and pre-probe trial intrahippocampal ca1 administration of 3 alpha-anderostanediol (one of the metabolites of testosterone) and indomethacin (as 3 alpha-hydroxysteroid dehydrogenase enzyme blocker) on acquisition, consolida...

Background: Opioids have been shown to affect learning and memory processes. Different protocols of morphine withdrawal can substantially vary in their success to prevent opioid induced impairments of cognitive performance. In the present study, we report the effects of single and repetitive ultra-rapid detoxification (URD) on spatial learning and memory in morphine addicted rats. Methods: Morp...

lead (pb2+) is a well known neurotoxin that was frequently found in the environment and chronic exposure to lead has been matter of public health. in the present study the effect of lead on spatial memory in developmentally exposed rats and their dams in morris water maze task were investigated. female rats were divided into three groups and two groups exposed to 250 and 750 part per million (p...