The development of new biopharmaceuticals relies on robust scale-up from small-scale screening studies to industrial bioreactors. Novel SUB designs can prove highly beneficial, although they lack the extensive characterisation traditional STRs. Pall Corporation’s Allegro™ STR 50-2000 L bioreactor range has a unique design square cross-section, with three wedge-shaped baffles. A scale-down 1 pro...

In recent years, a myriad of new statistical methods have been proposed for detecting associations of rare single-nucleotide variants (SNVs) with common diseases. These methods can be generally classified as 'collapsing' or 'haplotyping' based. The former is the predominant class, composed of most of the rare variant association methods proposed to date. However, recent works have suggested tha...

MOTIVATION Some economically important plants including wheat and cotton have more than two copies of each chromosome. With the decreasing cost and increasing read length of next-generation sequencing technologies, reconstructing the multiple haplotypes of a polyploid genome from its sequence reads becomes practical. However, the computational challenge in polyploid haplotyping is much greater ...

Haplotyping, also known as haplotype phase prediction, is the problem of predicting likely haplotypes based on genotype data. One fast haplotyping method is based on an evolutionary model where a perfect phylogenetic tree is sought that explains the observed data. Unfortunately, when data entries are missing, as is often the case in real laboratory data, the resulting formal problem IPPH, which...

In this report, we compared haplotyping approaches using families and unrelated individuals on the simulated rheumatoid arthritis (RA) data in Problem 3 from Genetic Analysis Workshop (GAW) 15. To investigate these two approaches, we picked two representative programs: PedPhase and fastPHASE, respectively, for each approach. PedPhase is a rule-based method focusing on the haplotyping constraint...

An efficient rule-based algorithm is presented for haplotype inference from general pedigree genotype data, with the assumption of no recombination. This algorithm generalizes previous algorithms to handle the cases where some pedigree founders are not genotyped, provided that for each nuclear family at least one parent is genotyped and each non-genotyped founder appears in exactly one nuclear ...

Chinese species of the subgenus Paederus s. str. (genus Paederus Fabricius, 1775) are reviewed. Paederus (s. str.) xinjiangensis Li & Zhou, n. sp. is described from Xinjiang, Northwest China. Male genitalia and other critical characters are illustrated for five other Chinese species of the subgenus Paederus s. str., namely P. (s. str.) socius Bernhauer, 1916, P. (s. str.) coxalis Fauvel, 1895, ...

Single nucleotide polymorphisms (SNPs) within a gene region have often been studied to determine their effect on phenotype. Although a single base pair change can produce a phenotypic change, phenotype is often influenced by the presence of multiple polymorphisms and their relative positions within a given region. For example, if multiple changes occur in a promoter region, how they influence g...