Background The majority of BRCA1-mutant breast cancers are characterized by a triple-negative phenotype and basal-like molecular subtype, associated with aggressive clinical behavior. Current treatment options limited, highlighting the need for development novel targeted therapies this tumor subtype.

background: the h9n2 subtype of influenza a viruses is considered to be widespread in poultry industry. adamantane is a group of antiviral agents which is effective both in prevention and treatment of influenza a virus infections. these drugs inhibit m2 protein ion channel which has role on viral replication. objectives: the main objective of this study is to evaluate m gene of avian influenza ...

background: cryptosporidium is an intestinal protozean parasite causing water­borne and foodborne outbreaks of diarrheal diseases. the present study was per­formed in order to find prevalence and subtypes of cryptosporidium among children with diarrhea in gonbad kavoos city, northern iran. methods: diarrheic samples were collected from 547 children. the initial parasitologi­cal diagnosis was ma...

Susceptibility to autologous and heterologous neutralization of primary human immunodeficiency virus (HIV)-1 isolates belonging to subtype B, to the B"-variant of subtype B or to subtype F from infected individuals residing in Rio de Janeiro was assayed. A lower infectivity of the B"- and F isolates when compared to the classical B-subtype HIV-1 isolates was observed. Comparisons of neutralizat...

【目的】大腿骨転子部骨折の骨折型，術後整復位とラグスクリュースライディング量の関係を検討すること．【方法】2019年7月～2021年6月に施行した大腿骨転子部骨折手術のうち，術後4ヶ月以上フォローし得た71例72関節（平均年齢85歳）を対象とした．骨折型は中野3D-CT分類，術後整復位は術後単純X線側面像の生田分類で評価した．スライディング量は術直後と術後4ヶ月の単純X線正面像を比較した．【結果】Subtype別の安定型骨折/不安定型骨折のスライディング量はsubtype Nにのみ有意差を認め，3.9 mm/6.7 mm（p＝0.049）であった．不安定型の術後subtype A/Nのスライディング量は3.4 mm（p＝0.030）でありsubtype Nで有意に大きかった．術後4ヶ月でのsubtype N→Pの矯正損失率は安定型42％（13/31），不安定型88％（7/8）であり，...

The distribution of hepatitis C virus (HCV) genotypes was determined in isolates of 447 chronically HCV-infected German patients by nucleotide sequencing. Of these, 206 (46.1%) were infected with the subtype 1a, 215 (48.1%) with subtype 1b, 2 (0.4%) with subtype 1c, 9 (2.0%) with subtype 3a, and 15 (3.4%) with subtype 4a. Subtype 1a was predominant in those < 40 years old (62.6%) and was associ...

INTRODUCTION Centrilobular emphysema (CLE) is recognized as low attenuation areas (LAA) with centrilobular pattern on high-resolution computed tomography (CT). However, several shapes of LAA are observed. Our preliminary study showed three types of LAA in CLE by CT-pathologic correlations. This study was performed to investigate whether the morphological features of LAA affect pulmonary functio...