Extensive experimental and clinical studies of the last five years have established the advantages of sulphonamide mixture therapy. 1-17 In brief the rationale for the use of mixtures is as follows: The renal toxicity of most of the newer sulphonamides, if used singly, is due primarily to over-saturation of the tubular urine with a sparingly soluble sulphonamide and/or its metabolic product, re...

Several methods are available for testing the sensitivity of organisms to the sulphonamide drugs (Harper and Cawston, 1945; Evans, 1948; Kokko, 1947), but none of them is entirely suitable for clinical use. The main difficu'ty in using a test similar to that for the antibiotics is the presence of sulphonamide-antagonizing substances in routine media. Such substances were first found in peptone ...

PAINFUL and frequent micturition are symptoms commonly encountered in general practice particularly in females. Examination of a mid-stream urine specimen reveals significant bacteriuria in about half the females with symptoms implying that bacteria are actually multiplying in the bladder urine. (Kass, 1956; Mond et al, 1965). Prevalence figures vary according to the criterion of infection adop...

poly(p-n-chlorostyrenesulphonamide) synthesized via direct chlorination of poly[(p-styrene) sulphonamide], can be used for selective chlorination of aromatic compounds. aromatic rings of the anisole, p-xylene, ethylbenzene and toluene are chlorinated with good yields. the polymer can be recovery, rechlorinated and reused several times.

OBJECTIVES To determine the genetic basis for tetracycline and sulphonamide resistance and the prevalence of class I and II integrons in oxytetracycline-resistant Acinetobacter spp. from integrated fish farms in Thailand. METHODS A total of 222 isolates were screened for tetracycline resistance genes [tet(A), tet(B), tet(H), tet(M) and tet(39)] and class II integrons by PCR. One hundred and t...

SYNOPSIS From 1966 to 1971, 298 cultures of meningococci from clinical material (cerebrospinal fluid or blood) were examined. Eighty-nine cultures were from the Manchester area and the remainder from other parts of England or Northern Ireland. Five per cent of strains were group A, 57% group B, and 31 % group C; 6% were untypable. Eighteen strains (6 %) had an MIC of 6 4 ,ug/ml or more of sodiu...