Drugs-of-abuse screening is becoming more prevalent, and a major technical and legal concern is that individuals may be mistakenly identified as drug usersbecause of a false-positive test result. Marijuana use can be detectedby screening a urine specimen with the Abbott (North Chicago, IL) TDx cannabinoid assay, which gives a positive reaction with several delta-9-tetrahydrocannabinol (THC) der...

One agent used by ophthalmologists to aid in funduscopic examinations is sodium fluorescein (“Funduscein,” Cooper Vision). We recently received a patient’s specimen for measurement of thyroxin (T4) and T3-uptake, drawn one day after she had been examined by an ophthalmologist. Owing to the high background fluorescence (62 580 arb.units) and low background polarization (24 mPol), no results were...

The cross-reactivity of fosphenytoin, a phosphate ester prodrug of phenytoin, was investigated in the Abbott phenytoin TDx/TDxFLx fluorescence polarization immunoassay (TDx) and the Behring Diagnostics phenytoin Emit 2000 enzyme-multiplied immunoassay (Emit). The first part of our study investigating cross-reactivity utilized in vitro correlation of the two immunoassays with a validated and spe...

"TDx Fetal Lung Maturity," an automated assay that measures the relative concentrations of surfactant and albumin in amniotic fluid, was compared with the lecithin/sphingomyelin (L/S) ratio and phosphatidylglycerol determination at five clinical sites. A total of 695 amniotic fluid samples were analyzed, of which 312 were followed by delivery of the infant within three days of sample collection...

ADVERTIMENT. L'accés als continguts d'aquesta tesi doctoral i la seva utilització ha de respectar els drets de la persona autora. Pot ser utilitzada per a consulta o estudi personal, així com en activitats o materials d'investigació i docència en els termes establerts a l'art. 32 del Text Refós de la Llei de Propietat Intel·lectual (RDL 1/1996). Per altres utilitzacions es requereix l'autoritza...

The Abbott TDx therapeutic drug-monitoring system is based on fluorescence polarization. Polarization fluoroimmunoassay makes use of competitive binding, measuring the tracer binding directly, without the need for separation procedures. The attraction of non-radioactive polarization fluoroimmunoassay for the determination of T-uptake is that there is no radiation hazard and that the homogeneous...