Antitumor Activity, Phosphorus Compounds A series of pentavalent phosphorus compounds containing the nitroxyl and/or aziridinyl moieties was evaluated for antitumor activity against P 388 and L 1210 lymphocytic leukemias, and compared to the clinical agent thio-TEPA (1). The compounds with the structures 5-13 were found to be active, with a T/C value greater than 125. The percent ILS was also d...

Seventy-eight patients were treated with intravesical instillation of Thio-Tepa in an attempt to prevent postoperative recurrences of bladder tumors. Fifty-six patients who were given no preventive treatment against recurrences were taken as the control group. The patients in this series presented at the Okayama University Hospital between 1961 and 1976 and only the first recurrence after the p...

MAC it happen : Presented is a study of the synergistic structuredirecting effect of metal–amine complexes (MACs) with different chelating polyamine ligands and imidazolium-based ionic liquid (IL) cations. For the first time, a layered selenidostannate with an asymmetric eight-membered ring, an organic-decorated layered selenidostannate, and a 3D selenidostannate with both the MAC and IL cation...

Microporous activated carbon fibers (ACFs) were developed for CO₂ capture based on potassium hydroxide (KOH) activation and tetraethylenepentamine (TEPA) amination. The material properties of the modified ACFs were characterized using several techniques. The adsorption breakthrough curves of CO₂ were measured and the effect of relative humidity in the carrier gas was determined. The KOH activat...

Previous studies have demonstrated that copper up-regulates hypoxia-inducible factor 1 (HIF-1). The present study was undertaken to test the hypothesis that copper is required for HIF-1 activation. Treatment of HepG2 cells with a copper chelator tetraethylenepentamine (TEPA) or short interfering RNA targeting copper chaperone for superoxide dismutase 1 (CCS) suppressed hypoxia-induced activatio...

The clinical use of alkylating drugs represents an important contribution toward the chemotherapeutic management of certain forms of human cancer. Several recent reports summarize the palliative responses obtained with triethylenemelamine (TEM), triethylene phosphoramide (TEPA), and Myleran (Busulfan) in patients with malignant neoplasias of lymphatic or myelogenous origin (2, 3, 11, 12). The c...

The paper reports the development of a microfluidic chip-capillary electrophoresis device using UV/Vis detection for profiling of urinary markers with adjustable on-chip sample dilution. A PMMA polymer microfluidic chip-CE device with on-chip ferrofluid valve control for adjustable sample dilution is developed for profiling of urinary markers related to metabolism disorders for clinical diagnos...