Although the architecture of a dopaminergic (DA) system within the primary motor cortex (M1) was well characterized anatomically, its functional significance remained obscure for a long time. Recent studies in rats revealed that the integrity of DA fibers in M1 is a prerequisite for successful acquisition of motor skills. This essential contribution of DA for motor learning is plausible as it m...

Objective Anti-Rh D IgG is used for the prevention of anti-D antibody production in Rh- individuals who have been exposed to Rh+ red blood cells. The stability of IgG preparations as a solution is low, with a shelf life of a year or more. Formulation of anti-Rh D IgG as a lyophilized preparation would decrease its degradation rate and increases its shelf life. The objective of this study was t...

Background: The aim of this study was to formulate and evaluate the noble herbal moisturise gel containing Stevia extract. Methods: The cosmetic gel formulation was designed by using aqueous extract of Stevia rebaudiana leaves in varied concentrations (2.5% and 5.0%) and evaluated using physiological measurements in comparision with a control placebo gel. The initial physicochemical parameters ...

chemotherapy research highly prioritizes overcoming the multidrug resistance (mdr) in human tumors. liposomal formulation of fluoxetine, as a fourth generation chemosensitizer, was constructed and characterized for percent entrapment, release profile, morphology, particle size, zeta potential and stability. liposomes were prepared using different active loading techniques. the influence of diff...

Screening for pharmaceutically viable stability from measurements of thermally induced protein unfolding and short-term accelerated stress underpins much molecule design, selection, and formulation in the pharmaceutical biotechnology industry. However, the interrelationships among intrinsic protein conformational stability, thermal denaturation, and pharmaceutical stability are complex. There a...

Long-term intensive use of mineral fertilizers in double rice-cropping systems has led to soil acidification and degradation. Manure fertilization was suggested as an alternative strategy mitigate However, the effects long-term manure on rice grain yield, yield stability, organic carbon (SOC) content, total nitrogen (TN) underlying mechanisms are unclear. Based a experiment established 1981 sou...

the study area is located at the sanandaj-sirjan zone in the west and north-west of azna and north-east of doroud, iran. the quartz-schists are divided into two main groups: amphibole-quartz schist and garnet-quartz schist. field and microstructural studies show several deformational phases. the d1 episode which is represented by s1, matches with m1 metamprphism and d2 deformation matches with ...

A formulation for finite element analysis of tapered and  monosymmetric I shaped beam-columns is presented. This is a general way to analyze these types of complex elements. Based upon the formulation, member stiffness matrix is obtained explicitly. The element considered has seven nodal degrees of freedom. In addition, the related stability matrix is found. Numerical studies of the aforementio...