Four hundred adults presenting with acute watery diarrhoea were entered into a randomised, placebo controlled, double blind clinical trial of berberine, tetracycline, and tetracycline and berberine to study the antisecretory and vibriostatic effects of berberine. Of 185 patients with cholera, those given tetracycline or tetracycline and berberine had considerably reduced volume and frequency of...

Tetracycline has been a widely used antibiotic because of its low toxicity and broad spectrum of activity. However, its clinical usefulness has been declining because of the appearance of an increasing number of tetracycline-resistant isolates of clinically important bacteria. Two types of resistance mechanisms predominate: tetracycline efflux and ribosomal protection. A third mechanism of resi...

This study investigated the levels of the antibiotic tetracycline contained in cow milk, goat milk, butterfat, soft cheese and yoghurt samples. High performance liquid chromatography (HPLC) standard methods were used for the detection and quantification of tetracycline in 40 dairy products samples. All the analysed samples contained residues of tetracycline antibiotics. The mean tetracycline re...

Background: Tetracycline antibiotics are widely used for prevention and control of disease. However, the presence of tetracycline antibiotics residues in food is a serious public health concern because of the harmful effects of these residues on consumer's health. Therefore, it is necessary to detect tetracycline residues in food of animal origin keeping in view the food safety issues and probl...

Calves were fed Escbericbia coli of bovine origin containing an R factor with resistance determinants found rarely in human and bovine populations. Some of these calves received tetracycline. Fecal samples from human subjects in daily contact with the calves were analyzed for the R factor, the bovine E. coli, and changes in the levels of tetracycline resistant coliforms. Crossover from the calv...

The Pseudomonas R factor RP1 determines an inducible tetracycline resistance similar to that described for Escherichia coli R factors. The level of RP1-determined resistance measured by minimal inhibitory concentration testing is dependent on the host bacteria and corresponds to the magnitude of decrease in tetracycline accumulation by RPl-containing organisms. The tetracycline resistance mecha...