BK virus (BKV) is a common opportunistic pathogen in kidney transplant recipients and one of the most challenging causes allograft dysfunction loss. Although over-immunosuppression remains primary risk factor for BKV infection after transplantation, male gender, older recipient age, prior rejection episodes, degree human leukocyte antigen mismatching, prolonged cold ischemia time, serostatus ur...

Natalizumab-treated patients have a higher risk of developing progressive multifocal leukoencephalopathy. Exposure to John Cunningham virus (JCV) is a prerequisite for PML (progressive multifocal leukoencephalopathy). To assess JCV exposure in multiple sclerosis patients, we performed a serological examination, obtained the antibody index, performed real-time polymerase chain reaction (PCR) to ...

BK virus (BKV)-specific immunity is critical for polyomavirus-associated nephropathy, but antibody responses are incompletely defined. We compared the hemagglutination inhibition assay (HIA) with immunoglobulin G enzyme immunoassays (EIA) to BKV proteins expressed in baculovirus-infected insect cells. N-terminal, internal, and C-terminal domains of the BKV large T antigen (BKLT) were fused to g...

Abstract Background and Aims BK virus infection continues to be one of the most common clinical issues encountered by transplants providers, which can lead nephropathy and, ultimately, graft loss. Despite its importance, there are still many uncertainties surrounding effective prevention treatment strategies. The aim this study is evaluate prevalence disease in a cohort kidney transplant patien...

BKV associated nephropathy (BKVAN) is a cause of renal dysfunction and loss of the graft in transplants. Viral primary infection is usually inapparent and then BKV establishes latency in kidneys. Reactivation occurs in immunocompromised conditions in renal transplant recipients who can develop a subclinical nephritis and eventually a BKV-associated interstitial nephritis or a BKVAN. In this stu...

Twenty-one out of 32 apparently healthy blood donors aged 21 to 65 years yielded positive complement fixation tests with a cytomegalovirus antigen, at titres ranging from 1:8 to 1:64. Virus was present in leucocyte cultures of fresh peripheral blood of two seropositive subjects from a total of 35 donors examined. Plasma and 48-hour stored blood specimens failed to disclose virus in culture. Vir...

A prospective study of epidemiology and pathogenesis of cytomegalovirus (CMV) infections in transplant recipients, previously reported for 30 patients (Clin. Res. XXII, 441A, 1974), has been extended to include 35 patients who have been studied clinically and virologically for 5 to 19 months after renal transplantation (RT) (except three patients who died within three months after RT). Active C...