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We describe the detection of Bordetella holmesii as a cause of whooping cough in Spain. Prevalence was 3.9% in 2015, doubling to 8.8% in 2016. This emergence raises concern regarding the contribution of B. holmesii to the reemergence of whooping cough and the effectiveness of the pertussis vaccine.

background: re-emergence of pertussis has been reported in iran despite a high rate of vaccination coverage. low efficacy of the vaccine might be due to the genetic divergence between clinical versus vaccine strains. in the current study, the genetic profiles of clinical isolates and vaccine strains of bordetella pertussis (b. pertussis) were assessed by using pulsed field gel electrophoresis (...

background whooping cough is caused by bordetella pertussis, and it remains a public health concern. whole-cell pertussis vaccines have been commonly employed for expanded immunization. there is no doubt of the efficacy of whole cell pertussis vaccine, but it is necessary to improve the vaccine to decrease its toxicity. objectives in this study, an inactivation process of dealing with pertussis...

The more important criteria for identification of the S form of H. pertussis and for its differentiation from R variants are presented in summary fashion in Table IV. The differences as indicated in detail in the foregoing sections and as shown briefly in this tabulation are so clear-cut that they call for little, if any, further comment. Of all the differential characteristics, the morphologic...

It is the purpose of this paper to report a case in which fatal convulsions occurred during convalescence from whooping cough, at a time when paroxysms of coughing were absent. This case is not unique, a similar one having been reported by Hiller and Grinker (1930). These authors point out that while air embolism or circulatory stasis may be a satisfactory explanation of convulsions associated ...

To the Editor, The Indian Medical Gazette. Sir,?In the Medical Annual for 1931 it is stated that the paroxyms of whooping cough can be arrested by vaccination against small-pox, but since this method of treatment was recommended in the early part of the present century, it cannot be claimed as something new, but only as something forgotten and revived. Vaccination was recommended as a method of...