results bahaodowle razi, a persian physician from the 15th century anno domini (ad), reported two epidemics in harat and one in rey (inold persia) for the first time, one century before baillou. he named it as sorfe-ie-am (meaning public cough). those occurred during his lifetime. explaining about his observations and experiences about this epidemic, bahaodowle razi elaborated on prognosis, sym...

background: recent studies indicate an increased incidence of pertussis disease in recent years. the aim of this study was to evaluate the efficacy of the acellular vaccine for children (as a replacement of current whole cell vaccine in the expanded program on immunization) and for high-risk adults in iran through updating current best available evidence.   methods: we performed a systematic li...

results the results showed that all the strains had the dominant allele ptxs1a. there were differences between the alleles of the clinical strains and the vaccine strain. conclusions in recent years, a significant increase in the incidence of pertussis has been reported worldwide. our findings regarding the allelic shift of the ptxs1 gene are similar to those reported in many european and ameri...

background pertussis is a respiratory and contagious disease which is mostly caused by bordetella pertussis and b. parapertussis. it usually spreads from person to personduring the incubation or catarrhal phase of the disease. despite of large-scale vaccination, whooping cough is still an endemic disease with several outbreaks. objectives the aim of this study was to determine the prevalence of...

Following the isolation of the pertussis bacillus by Bordet and Gengou' in 1906, anticipation of methods of control of whoopingcough was inevitable. This discovery gave impetus to experimental and clinical investigations on various aspects of the whooping-cough problem. The isolation of the apparent causative agent, the introduction of new bacteriologic aids in early diagnosis, the transmission...

In a case-control study 27 index children from ordinary schools who had had convulsions or apnoea as a complication of whooping cough about eight years previously were compared with 27 children who had never had whooping cough and 15 who had had whooping cough without complications. Other factors likely to cause intellectual impairment after conception were considered. The index group had a sig...