UNLABELLED (J Diabetes Invest, doi: 10.1111/j.2040-1124.2012.00223.x, 2012) Aims/Introduction:  We assessed the efficacy of liraglutide therapy in Japanese type 2 diabetic patients insufficiently controlled with basal-supported oral therapy (BOT). MATERIALS AND METHODS   We retrospectively analyzed the data of 37 patients who had postprandial hyperglycemia (≥10.0 mmol/L) with BOT (long-acting...

Given the ubiquity and evolutionary importance of parasites, their effect on the energy budget of mammals remains surprisingly unclear. The eastern chipmunk (Tamias striatus (L., 1758)) is a burrowing rodent that is commonly infected by cuterebrid bot fly (Cuterebra emasculator Fitch, 1856) larvae. We measured resting metabolic rate (RMR) and cold-induced VO2-max (under heliox atmosphere) in 20...

OBJECTIVE To determine the clinical usefulness of basal-supported oral therapy (BOT) using insulin glargine in Japanese patients with type 2 diabetes. METHODS We compared HbA1c levels, body weight, and insulin doses before the introduction of BOT and in the final month of the observation period in 122 patients with type 2 diabetes who received BOT with insulin glargine between October 2007 an...

AIMS Little is known about routine use of basal insulins [glargine, detemir, neutral protamine Hagedorn (NPH)] in primary care patients with type 2 diabetes. The aim was to compare injection frequencies of basal insulins in type 2 diabetes in primary care practices, both for basal-supported oral therapy (BOT) and basal-bolus treatment [intensified conventional therapy (ICT)] regimens. METHODS...

The paper deals with the problem of modeling key features of the Web traffic generated by Internet bots, observed at the input of a Web server. Based on real log data of an online store, a set of bot sessions was prepared and analyzed. Three session features connected with bots’ arrival process at the server were analyzed: session interarrival time, request interarrival time, and the number of ...

BACKGROUND Due to the progressive nature of type 2 diabetes mellitus (T2DM), antidiabetic treatment needs to be continuously intensified to avoid long-term complications. In T2DM patients on either basal insulin-supported oral therapy (BOT) or supplementary insulin therapy (SIT) presenting with HbA1c values above individual targets for 3-6 months, therapy should be intensified. This study inves...

Massive Online Open Courses (MOOCs) which were introduced in 2008 has since drawn attention around the world for both its advantages as well as criticism on its drawbacks. One of the issues in MOOCs which is the lack of interactivity with the instructor has brought conversational bot into the picture to fill in this gap. In this study, a prototype of MOOCs conversational bot, MOOC-bot is being ...