نتایج جستجو برای: سرطان سلول سنگفرشی مری پلیمورفیسم ژنهای nqo1 cyp2c9 gstt1 gstm1 pah
تعداد نتایج: 37048 فیلتر نتایج به سال:
مقدمه : سرطانهای دستگاه گوارش فوقانی یکی از مشکلات بهداشتی درمانی مهم و از شایعترین سرطانهای منجر به مرگ در سراسر جهان و کشور ما به شمار می رود . هدف مطالعه : بررسی ویژگیهای جمعیت شناختی و بالینی بیماران مبتلا به سرطانهای دستگاه گوارش فوقانی مراجعه کننده به بیمارستان فوق تخصصی شهدای عشایر شهر خرم آباد در سال 1390-1389 می باشد . مواد و روشها : ین مطالعه مقطعی روی 87 بیمار مبتلا به سرطانهای...
BACKGROUND GST is a family of enzymes that are important in protection of the body against oxidative stress. OBJECTIVES Investigate the association between GSTT1 and GSTM1 polymorphism and hypertension. MATERIALS AND METHODS GSTT1 and GSTM1 genotypes were detected by PCR. The fragments were then analyzed by agarose gel electrophoresis. RESULTS There is no significant association between G...
BACKGROUND Deletion types of genetic variants of glutathione S-transferase (GST) M1 and T1, the GSTM1 null and GSTT1 null which are risk factors for certain cancers, have been ubiquitously found in human populations but their worldwide distribution pattern is unclear. MATERIALS AND METHODS To perform a meta-analysis, a systematic search for the literature on GSTM1 and GSTT1 null genotypes was...
BACKGROUND Glutathione S-transferases (GST) detoxify a broad range of carcinogenic metabolites and lack of GSTM1 and GSTT1 activity due to gene deletions are prevalent. The associations of GSTM1 and GSTT1 polymorphisms with endometrial cancer risk have been inconsistent. METHODS We investigated gene dosage effects of GSTM1 and GSTT1 copy number in 441 endometrial cancer cases and 1,237 matche...
UNLABELLED Occupational exposure to polycyclic aromatic hydrocarbons (PAH) increases the risk of developing lung cancer. Human exposure is often demonstrated by increased internal levels of PAH metabolites and of markers for early biological effects, like DNA adducts and cytogenetic aberrations. OBJECTIVE This study aimed to assess whether the current exposure to PAH of coke oven workers in a...
OBJECTIVE Insulin-like growth factor-1 (IGF-1) is essential for the pubertal growth spurt and for normal mammary gland development. IGF-1 increases premenopausal breast cancer risk. Oral contraceptives (OCs) decrease IGF-1 in most women. The endogenous estrogens and their metabolites also influence IGF-1 levels. Glutathione S-transferases (GSTs) are involved in estrogen metabolism. We aimed to ...
Objective(s):To the best of our knowledge, this is the first report on the contributions of GST genetic variants to the risk of diabetic retinopathy in an Iranian population. Therefore, the objective of this study was to determine whether sequence variation in glutathione S-transferase gene (GSTM1 and GSTT1) is associated with development of diabetic retinopathy in type 2 diabetes mellitus (T2D...
Background & Aims: Recurrent Pregnancy Loss (RPL) is defined as two or more consecutive spontaneous abortions. Glutathione S-transferase genes produce isoenzymes that protect embryo against oxidative stress. The aim of this study was to determine the removal of the two genes, GSTT1 and GSTM1 in male partners of couples having RPL. Materials & Methods: A case-control study of 102 cases w...
glutathione s-transferases (gsts; ec: 2.5.1.18) are ubiquitous multifunctional enzymes, which play a key role in cellular detoxification. functional genetic polymorphisms in genes encoding gstm1 (a member of gst class mu; omim: 138350), and gstt1 (a member of gst class theta; omim: 600436) have been well defined. the functional null alleles of gstm1 and gstt1 represent deletions of gstm1 and gs...
دیابت ملیتوس، یک اختلال معمول و پیچیده است که اهمیت آن در جهان به سرعت روبه افزایش می باشد. این بیماری توسط هیپرگلیسمی مزمن شناخته می شود و با افزایش تولید گونه های فعال اکسیژن (ros) همراه است. آنزیم های آنتی اکسیدان از جمله گلوتاتیون s-ترانسفراز، در جمع آوری رادیکال های آزاد نقش مهمی دارند امّا عدم تعادل میان مکانیسم های دفاعی سلول و تولید ros می تواند موجب تجمع این رادیکال ها، ایجاد استرس اکسی...
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