نتایج جستجو برای: سیستم 1α آدرنرژیک
تعداد نتایج: 88057 فیلتر نتایج به سال:
تاکنون مطالعات بسیاری اثرات مورفین را به عنوان آگونیست رسپتورهای اوپیوئیدی بر آستانه تشنجات کلونیک مورد بررسی قرار داده اند اگرچه هنوز مکانیسم دقیق دخیل در بروز این اثرات مشخص نشده است.پژوهش های اخیر نشان می دهند سیستم اپیوئیدی و سیستم آدرنرژیک در بسیاری از اثرات مربوط به سیستم عصبی مرکزی از جمله ایجاد و تثبیت حافظه با یکدیگر برهم کنش دارند. بعلاوه پروپرانولول به صورت وابسته به دوز بر آستانه تش...
Objective: Decreased physical activity coupled with increased High‐Fat Diet (HFD) intake prompts obesity. Current research suggests that changing White Adipose Tissue (WAT) to brown promotes energy expenditure to counter obesity. The purpose of this study was to investigate the effects of aerobic Progressive training and Capsaicin (Cap) on Peroxisome proliferator-activated receptor gamma coacti...
Background: The purpose of this study was to compare the effects of a 12 weeks interval training with high and moderate intensity on PGC-1α of skeletal muscle in type 2 diabetic male rats. Methods: 40 male rats were divided into two groups: High fat diet (HFD) (n=32) and standard diet (C) (n=8) for 10 weeks. After inducing type2 diabetes via STZ, 8 diabetic rats (D) and 8 rats in group C rats ...
آزمایشی برای بررسی اثر افزودن متابولیت 1- آلفا هیدروکسی کولهکلسیفرول با و بدون کولهکلسیفرول و فیتاز میکروبی در جیرههای با سطوح مختلف کلسیم و فسفر بر عملکرد جوجههای گوشتی انجام شد. برای انجام این آزمایش تعداد 576 قطعه جوجه یک روزه نر (راس 308) با میانگین وزن 1±40 گرم انتخاب شدند. آزمایش در قالب طرح کاملا تصادفی به صورت فاکتوریل (3×2×2×3) با 4 تکرار و 4 جوجه در هر تکرار انجام شد. فاکتورها ...
Objective(s): Previous study has indicated that triiodothyronine (T3) facilitated cartilage degeneration in osteoarthritis (OA). This study aimed to investigate the effects of T3 on angiogenesis-related factor expression in human osteoblasts of OA subchondral bone.Materials and Methods: The subchondral bone specimens were obtained from O...
Hypoxia-inducible factor-1α (HIF-1α) is known as a transactivator for VEGF gene promoter. It can be induced by hypoxia. However, no study has been done so far to dissect HIF-1α-mediated effects from hypoxia or VEGF-mediated effects. By using a HIF-1α knockout (HIF-1α KO) cell system in mouse embryonic fibroblast (MEF) cells, this study analyzes cell migration and HIF-1α, hypoxia and VEGF activa...
Background: Obesity is associated with increased risk of many diseases. Methylation is an important factor in obesity, indicating epigenetic changes. However, there is lack of data about PGC-1α methylation and regular exercise. Purpose of this study was to determine effects of 6-week high-intensity interval training (HIIT) on PGC-1α methylation in gastrocnemius muscle of obese male rats. Metho...
Shiga toxins (Stxs) are bacterial virulence factors produced by Shigella dysenteriae serotype 1 and Escherichia coli strains. Stxs are critical factors for the development of diseases such as severe bloody diarrhea and hemolytic uremic syndrome. Additionally, Stxs trigger the secretion of pro- inflammatory cytokines and chemokines, particularly in monocytes or macrophages. The inflammatory cyto...
Introduction: PGC-1α gene plays an important role in regulating cellular energy metabolism and stimulating the increased cell mitochondrial mass. Understanding the status of this gene polymorphism in non-athletic male adolescents may be helpful in choosing and identifying the sport talented male adolescents. The purpose of the present study was to investigate possible association between PGC-1α...
Adenoid hypertrophy (AH) can cause harmful effects on untreated children, which include mouth breathing, chronic intermittent hypoxia, sleep disordered breathing (SDB), and even some behavioral problems. However, the molecular mechanisms underlying this pathophysiological process have remained poorly understood. In study, SUMO was induced silencing overexpression using RNAi lentiviral-mediated ...
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