OBJECTIVE Mitogen-activated protein kinase phosphatase-1 (MKP-1) is one of several oxidized-l-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (Ox-PAPC)-induced genes identified in human aortic endothelial cells (HAEC). We previously reported that MKP-1 activity is required for Ox-PAPC-mediated endothelial/monocyte interactions; however, an in vivo role of MKP-1 in atherogenesis ...

The attraction, binding, and entry of monocytes into the vessel wall play an important role in atherogenesis. We have previously shown that minimally oxidized/modified LDL (MM-LDL), a pathogenically relevant lipoprotein, can activate human aortic endothelial cells (HAECs) to produce monocyte chemotactic activators. In the present study, we demonstrate that MM-LDL and oxidation products of 1-pal...

Background and Objective: Uropathogenic Escherichia coli (UPEC) are the most common cause of urinary tract infections. The binding of these bacteria to epithelial cells and the formation of biofilms cause these bacteria to be further colonized and difficult to remove in the urinary tract. This study aimed to determine the antibiotic resistance and to evaluate the biofilm formation power in Esch...

colibacillosis caused by e.coli is one of the most common illnesses in commercial chickens and induce high financial losses in the poultry industry due to morbidity, mortality and antibiotic expenses because of overuses. e.coli can mostly cause disease as a secondary or opportunistic pathogen, while certain strains with specific virulence factors even as primary pathogen can cause colibacillosi...

The chaperone/usher pathway is responsible for the assembly of adhesive pili on the surface of gram-negative pathogenic bacteria. In this issue, Remaut et al. (2008) present the crystal structure of the PapC usher translocation domain and images of the FimD usher bound to a pilus translocation intermediate. These new structures provide the first detailed view of a translocase in action.

In Uruguay, the mortality of dairy calves due to infectious diseases is high. Escherichia coli a natural inhabitant intestinal microbiota, but can cause several infections. The aim work was characterize E. isolates from and extraintestinal origin dead newborn calves. Using PCR, virulence gene characteristics pathogenic were searched. molecularly characterized phylogroup, serogroup Stx subtype d...