Insulin receptor substrate-1 (Irs1) is one of the major substrates for insulin and insulin-like growth factor-1 (IGF-1) tyrosine kinases. Systemic Irs1-deficient mice show retardation, with resistance to IGF-1, although underlying mechanisms remain poorly understood. For this study, we generated brain-specific deletion Irs1 (NIrs1KO mice). The NIrs1KO exhibited lower body weights, shorter bodie...

Background & Objective: In traditional medicine, leaves of white mulberry (Morus alba L.) are used as antidiabetic agents. Considering the presence of flavonoids, this plant exhibits insulin mimetic activities. Nesfatin-1 is described as an anorexigenic regulatory peptide, which can influence glucose metabolism via insulin sensitivity enhancement. This study examined the effects of both mulberr...

Background: There is not any in vivo studies that shows inducing of euglycemia by vanadyl is independent from plasma insulin.  Therefore in the present study we planned to investigate the antidiabetic effects of vanadyl in diabetic rats. Materials and Methods: Rats became severely diabetic by an IV injection of 50-55mg/kg streptozotocin (STZ), 15 days after the injection, the blood glucose of ...