1. Eighteen known or possible metabolites of the hepatic carcinogen 4- (or p-) dimethylaminoazobenzene were tested for carcinogenic activity in the rat. Of these compounds only 4-monomethylaminoazobenzene, a known metabolite, proved to be active. Eight compounds, which appear to be metabolites of the dye, were inactive; these included 4-aminoazobenzene, 4'-hydroxy-4-monomethylaminoazobenzene, 4...

Di(2-ethylhexyl) phthalate (DEHP), a commonly used plasticizer and microchemical environmental pollutant, produces subtle changes in hepatic function as judged by increase in liver weight and morphological and biochemical alterations. It can modify the biological response of drugs and other xenobiotics. Such interactions appear to occur at the pharmacokinetic phase, as DEHP was found to alter t...

Structural features of nucleic acids have become an integral part of current biomedical research. Highly selective and readily performed methods with little toxicity that target guanosines in non-duplex nucleic acids are needed, which led us to search for an effective agent for guanosine sequencing. Treatment of DNA or RNA with potassium tungstate and hydrogen peroxide produced damaged guanosin...

The conformation of the NH bond in the structure of the title compound (N34DMPBA), C(15)H(15)NO, is anti to the meta-methyl substituent in the aniline ring, similar to that observed with respect to the meta-chloro substituent in N-(3,4-dichloro-phen-yl)benzamide (N34DCPBA), but in contrast to the syn conformation observed with respect to the meta-methyl substituent in N-(3,4-dimethyl-phen-yl)ac...

In the title compound, C(15)H(14)ClNO, the N-H and C=O bonds in the amide group are anti to each other. The amide group is inclined at 60.3 (1)° to the chloro-substituted benzoyl ring and at 59.2 (1)° to the dimethyl-substituted aniline ring. The mean planes through the two benzene rings make a dihedral angle of 7.7 (1)°. In the crystal structure, mol-ecules are linked by inter-molecular N-H⋯O ...

The influence of hydrogen bonding (HB) and protonation on an intramolecular charge transfer (ICT) compound, such as N,N-dimethyl-4-(phenylimino-methyl)-aniline (NMe2-4PmA) in the ground and excited state with two protic solvents 2,2,2-trifluoroethanol (TFE) and 2,2,2-trichloroethanol (TCE) is investigated. Mono HB and mono protonation complexes with TFE and TCE both in the ground state as well ...

In the title compound, C(26)H(25)NO(6), the anthraquinone ring system forms a dihedral angle of 15.5 (1)° with the benzene ring of the dimethyl-aniline group. Intra-molecular O-H⋯O hydrogen bonding is observed between the carbonyl and two hydroxyl groups. The mol-ecules are linked into a ribbon-like structure along the [100] direction by O-H⋯N and C-H⋯O hydrogen bonds. The crystal used was twin...