Numerical simulations are playing an important role in solving complex problems and have the potential to revolutionize medical decision making and treatment strategy. Musculoskeletal conditions cost the U.S. economy alone over $849 billion per year (7.7% of the U.S. Gross Domestic Product) and place great demands on healthcare systems worldwide [1]. This area could greatly benefit from computa...

94. Van Quaquebeke, E.; Simon, G.; Andr, A.; Dewelle, J.; El Yazidi, M.; Bruyneel, F.; Tuti, J.; Nacoulma, O.; Guissou, P.; Decaestecker, C.; Braekman, J.C.; Kiss, R.; Darro, F. Id entification of a novel cardenolide (2''-oxovoruscharin) from Calotropis procera and the hemisynthesis of novel derivatives displaying potent in vitro antitumor activities and high in vivo tolerance: structureactivit...

Under 5 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4,476 6.5 5 to 9 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4,449 6.5 10 to 14 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4,221 6.1 15 to 19 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6,268 9.1 20 to 24 years . . . . . . . . . . . . . . . . ....

BACKGROUND Human cytomegalovirus (CMV) is prevalent in older adults and has been implicated in many chronic diseases of aging. This study investigated the relation between CMV and the risk of Alzheimer disease (AD). METHODS Data come from 3 cohort studies that included 849 participants (mean age [±SD], 78.6 ± 7.2 years; mean education duration [±SD], 15.4 ± 3.3 years; 25% black). RESULTS A ...

Ultrahigh-dimensional variable selection plays an increasingly important role in contemporary scientific discoveries and statistical research. Among others, Fan and Lv [J. R. Stat. Soc. Ser. B Stat. Methodol. 70 (2008) 849–911] propose an independent screening framework by ranking the marginal correlations. They showed that the correlation ranking procedure possesses a sure independence screeni...

autoimmune haemolytic anemia in two children. Am J Clin Pathol 122:849–854 13. Reff ME, Carner K, Chambers KS et al (1994) Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20. Blood 83:435–445 14. Finazzi G (2002) Rituximab in autoimmune cytopenias: for which patients? Haematologica 87:113–114 15. Ghazal H (2002) Successful treatment of pure red cell aplasia with ...

Peking Insulin Structure Research Group (1974) Sci. Sin. 17,752-778 Sakabe, N., Sakabe, K. & Sasaki, K. (1981) Structural Studies on Molecules of Biological Interest, p. 509, Oxford University Press, Oxford Tager, H., Given, B., Baldwin, D., Mako, M., Markese, J., Rubinstein, A., Olefsky, J., Kobayashi, M., Kotterman, 0. & Poucher, R. (1979) Nature (London) 281,122-125 D. F. (1 98 1) Biochem. B...

Familial adenomatous polyposis (FAP) is responsible for <1% of colorectal cancer (CRC) cases and is inherited as an autosomal dominant trait. Patients generally present hundreds to thousands of adenomas and develop colorectal cancer by age 35- 40 if left untreated. Here we report four patients with germline frameshift mutation (small deletion) at exon 15 of adenomatous polyposis coli (APC) tumo...