نتایج جستجو برای: 7 receptor alpha multiple sclerosis

تعداد نتایج: 2036610  

Journal: :iranian journal of radiology 0
nasrin rahimian iranian center of neurological research, tehran university of medical sciences, tehran, iran hamidreza saligheh rad quantitative mr imaging and spectroscopy group, research center for cellular and molecular imaging, medical physics and biomedical engineering department, tehran university of medical sciences, tehran, iran kavous firouznia advanced diagnostic and interventional radiology research center (adir), tehran university of medical sciences, tehran, iran seyed amir ebrahimzadeh department of radiology, shohada-e-tajrish hospital, shahid beheshti university of medical sciences, tehran, iran alipasha meysamie community medicine department, medical faculty, tehran university of medical sciences, tehran, iran hamideh vafaiean quantitative mr imaging and spectroscopy group, research center for cellular and molecular imaging, medical physics and biomedical engineering department, tehran university of medical sciences, tehran, iran

results when the two ms groups were compared together, we found that cr was significantly increased (p value=0.008) and naa/cr was significantly decreased (p value=0.03) in non-enhancing lesions in ppms compared with rrms. there was no significant difference in naa, cho or naa/cho between the two ms subtypes. conclusion mrs is a potential way to differentiate ppms and rrms. objectives we compar...

Journal: :iranian journal of neurology 0
behnaz sedighi department of neurology, school of medicine, neurology research center, kerman university of medical sciences, kerman, iran. abbas pardakhty department of pharmacology ,school of pharmacy, pharmaceutics research center, neuropharmacology institute, kerman university of medical sciences, kerman, iran. hoda kamali department of neurology, school of medicine, neurology research center, kerman university of medical sciences, kerman, iran. kaveh shafiee department of neurology, school of medicine, neurology research center, kerman university of medical sciences, kerman, iran. bahar naz hasani department of neurology, school of medicine, neurology research center, kerman university of medical sciences, kerman, iran.

background: cognitive  impairment  is one of the  most crucial disorders  among  multiple  sclerosis (ms) patients. since  ms  is  an inflammatory disease   and   boswellia papyrifera has anti-inflammatory effects, the influence of b. papyrifera  on  cognitive  impairment   in  ms patients   has been investigated  in the present study. methods: in this clinical trial, 80 ms patients  who referr...

Background and purpose: Multiple sclerosis (MS) is a chronic autoimmune disease in which the myelin sheaths of nerve cells in the brain and spinal cord are damaged. The prevalence of disease is higher in women and it seems that sex hormones, which usually exert their effects through receptors, are involved in susceptibility to MS. Considering the functional role of Alu insertion 306 bp polymorp...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2013
Wangko Lundström Steven Highfill Scott T R Walsh Stephanie Beq Elizabeth Morse Ingrid Kockum Lars Alfredsson Tomas Olsson Jan Hillert Crystal L Mackall

Human soluble interleukin-7 receptor (sIL7R)α circulates in high molar excess compared with IL-7, but its biology remains unclear. We demonstrate that sIL7Rα has moderate affinity for IL-7 but does not bind thymic stromal lymphopoietin. Functionally, sIL7Rα competes with cell-associated IL-7 receptor to diminish excessive IL-7 consumption and, thus, enhances the bioactivity of IL-7 when the cyt...

Journal: :Current Opinion in Neurology 2020

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه تربیت مدرس - دانشکده علوم پزشکی 1391

مالتیپل اسکلروز (ms) یکی از شایع ترین بیماری های خودایمنی است که سیستم عصبی مرکزی را درگیر می کند.تاکنون علت اصلی این بیماری شناخته نشده است اما مطالعات اپیدمیولوژیکی به روشنی نشان می دهد که هم عوامل محیطی و هم عوامل ژنتیکی در ابتلا به این بیماری دخالت دارند. هدف از این تحقیق بررسی ارتباط یک سری پلی مورفیسم های تک نوکلئوتیدی موجود در پروموتر ژن مهار کننده nf-?bکه مهمترین آن ikb-? می...

Journal: :مجله علوم اعصاب شفای خاتم 0
fatemeh yardehnavi a. islamic azad university, mashhad branch, mashhad, iran b. member of mashhad neuroscience research group of islamic azad university, mashhad branch, mashhad, iran mahtab irani a. islamic azad university, mashhad branch, mashhad, iran b. member of mashhad neuroscience research group of islamic azad university, mashhad branch, mashhad, iran maryam nabipour a. islamic azad university, mashhad branch, mashhad, iran b. member of mashhad neuroscience research group of islamic azad university, mashhad branch, mashhad, iran

multiple sclerosis (ms) is an autoimmune disease of the central nervous system (cns) which causes demyelination of the nerve fibers. the etiology of this disease is not well understood but it is believed that t helpers play a central role in ms. numerous findings support the view that th17 cells play an essential role in pathogenesis of ms and il-17 secreting t (th17) cells have a role in infla...

Journal: :medical journal of islamic republic of iran 0
mh sanati from the national research center for genetic engineering and biotechnology, tehran, i. r. iran pr carnegie the biotechnology research grpup, murdoch university, western australia 6150, australia

when pooled immunoglobulin g (igg) from patients with multiple sclerosis (ms) was used to probe a human fetal spinal cord λgt 11 cdna library, the igg was found to bind to a predicted epitope of human mitochondrial nd4 sequence. to investigate the involvement of the nd4 as an autoantigen in ms, we determined the presence of specific antibody in the serum of ms patients and serum samples of some...

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