Cell imaging: The versatile synthesis, photophysical characterization and use of multiple Cinnoline/Naphthalimide fused hybrid fluorophores for live cell imaging provides a comprehensive overview “CinNapht” potential as bio-imaging agent.

2 Using Enantiomerically Resolved Cationic 4‐Amino-1,83 naphthalimide-Based Tröger’s Bases 4 Swagata Banerjee,† Sandra A. Bright,‡ Jayden A. Smith,† Jeremy Burgeat,† Miguel Martinez-Calvo,† 5 D. Clive Williams,‡ John M. Kelly,*,† and Thorfinnur Gunnlaugsson*,† 6 †School of Chemistry and Trinity Biomedical Sciences Institute, University of Dublin, Trinity College Dublin, Dublin 2, Ireland 7 ‡Sch...

The controlling kinetics of the water solubility of two synthesized mono azo naphthalimide based disperse dyestuffs in the presence of two different dispersing agents namely Irgasol DAM and lyoprint EV agents at various temperatures were investigated. An exponential rate equation was found to describe the dissolution process. The addition of Irgasol DAM and Lyoprint EV dispersing agents increas...

A new naphthalimide derivative bearing a tetrathia-azacrown for high affinity and selective binding to Cu(+) was synthesised. Copper recognition properties in solution were evaluated using (1)H NMR and fluorescence spectroscopy. Live cell imaging by confocal microscopy highlighted the capabilities of the new sensor for the two-wavelength detection of intracellular monovalent copper in neuronal ...

The synthesis and photophysical properties of 1 and 2, two Ru(II)-polypyridyl based-1,8-naphthalimide Tröger's bases, are described; these were found to stabilize double stranded DNA, undergo rapid cellular uptake, displaying good luminescence without affecting cell viability even after 24 hours of incubation.

We present the synthesis and characterisation of naphthalimide-flavin redox sensor 1 (NpFR1), a novel flavin molecule that is almost non-fluorescent in reduced form, but oxidation gives rise to a 125-fold increase in fluorescence. Confocal microscopy experiments confirm that is sensitive to redox changes within living cells.

Naphthalimides make up a class of organic molecules characterised by excellent spectroscopic properties due to their extended conjugate system. Furthermore, various asymmetric or symmetric compounds can be obtained from naphthalimides the different functionalization that performed on nitrogen and/or aromatic rings. The introduction wide range substituents in positions allows chemical and regula...

A novel bifunctional naphthalimide-based [12]aneN3 compound 1 was successfully applied as an effective non-viral gene vector in cancer cells, the fluorescence properties of 1 clearly demonstrated the process of cellular uptake, DNA translocation and release based on real-time fluorescence tracking.