OBJECTIVE To compare the incidence rates for AD among elderly African-American, Caribbean Hispanic, and white individuals and to determine whether coincident cerebrovascular disease contributes to the inconsistency in reported differences among ethnic groups. METHODS This was a population-based, longitudinal study over a 7-year period in the Washington Heights and Inwood communities of New Yo...

AIMS/INTRODUCTION Despite the use of intensive therapies, declining renal function is often observed during the overt nephropathy stage of type 2 diabetes. We aimed at investigating the role of serum uric acid (SUA) levels at the onset of overt nephropathy in the risk of renal function decline in type 2 diabetes patients. MATERIALS AND METHODS The present cohort study included 290 type 2 diab...

OBJECTIVE To assess the effect of introducing named accountable general practitioners (GPs) for patients aged 75 years on patterns of general practice utilisation, including continuity of care. DESIGN Regression discontinuity design applied to data from the Clinical Practice Research Datalink to estimate the treatment effect for compliers aged 75. SETTING 200 general practices in England. ...

BACKGROUND Mortality in HIV-infected patients who have access to highly active antiretroviral therapy (ART) has declined in sub-Saharan Africa, but it is unclear how mortality compares to the non-HIV-infected population. We compared mortality rates observed in HIV-1-infected patients starting ART with non-HIV-related background mortality in four countries in sub-Saharan Africa. METHODS AND FI...

OBJECTIVE To investigate the incidence of tinnitus that burdens the health service in England. DESIGN This was an observational study of 4.7 million residents of England under 85 years of age who were at risk for developing clinically significant tinnitus (sigT). SigT was defined by a discharge from hospital with a primary diagnosis of tinnitus, or a primary care recording of tinnitus with su...

Abstract Study question Is the survival rate of a cohort donor oocytes used for each recipient associated with outcomes cycle? Summary answer Oocyte cryo-survival rates (benchmark = 95-100%, competency 85-95%, below-competency 70-85%, and poor 50-70%) are not embryological clinical pregnancy in first transfer cycle. What is known already The use vitrified-warmed allows overcoming many logistic ...