BACKGROUND Intraoperative identification of parathyroid adenomas can be challenging. We hypothesized that low-doses methylene blue (MB) and near-infrared fluorescence (NIRF) imaging could be used to identify parathyroid adenomas intraoperatively. METHODS MB was injected intravenously after exploration at a dose of 0.5 mg/kg into 12 patients who underwent parathyroid surgery. NIRF imaging was ...

Primary hyperparathyroidism is characterized by increased synthesis and release of parathyroid hormone, which produces an elevated serum calcium level and a decline in serum inorganic phosphates. Asymptomatic patients are frequently diagnosed due to screening by automatic multi-chemistry panels. The vast majority of cases of primary hyperparathyroidism (80–85%) are due to single or multiple hyp...

Background: Diagnosis of coronary artery disease (CAD) in patients with left bundle branch block (LBBB) is considered as a challenge in cardiology due to the low accuracy of noninvasive methods such as basal and stress electrocardiography (ECG). This diagnostic challenge can be reduced but not eliminated using dipyridamole as a stress method instead of exercise. The aim of this study was to ass...

Scintimammography performed with Tc-99m sestamibi in a 63-year-old woman with a history of mitral valve replacement and pulmonary hypertension demonstrated that the frequently observed sternal hyperactivity on anterior views could arise from the myocardium. Caution therefore should be taken before the diagnosing hyperactivity in the lower sternal region as a neoplastic involvement. Fig. 1. Scin...

  Bilateral diffuse intense breast uptake was noted in a 40 year old female who was evaluated with Tc-99m sestamibi (MIBI) myocardial perfusion scan for possible ischemia. She was breast feeding her 1.5 year old child. The intense uptake in the breasts was superimposed on the apical and anteroapical regions of the myocardium and caused interpretation problem. We recom...

OBJECTIVES The purpose of this study was to determine how frequently and for what reasons the addition of electrocardiographically gated technetium-99m (Tc-99m) sestamibi single-photon emission computed tomographic (SPECT) images add value to nongated SPECT perfusion images. BACKGROUND Electrocardiographic gating of Tc-99m sestamibi SPECT images permits assessment of regional and global left ...

introduction: radio-guided parathyroid surgery along with other minimally invasive surgeries constitutes the main surgical treatment procedures for different kinds of hyperparathyroidism.  in this article we have reported our experience of radio-guided parathyroid surgery using tc-99m sestamibi. methods: ten patients with hyperparathyroidism included in our study. twenty mci of tc-99m sestamibi...

Nuclear medicine has been using radiopharmaceuticals for the diagnostic and therapeutic purposes of many diseases. Technetium-99m methoxyisobutylisonitrile (99mTc sestamibi) is a lypophilic complex that has a positive-loaded isonitril group. Aim of the study is to investigate whether 99mTc sestamibi, which is one of the mostly used radiopharmaceuticals in nuclear medicine field, causes oxidativ...

STUDY OBJECTIVES To evaluate dipyridamole stress echocardiography (DSE) for predicting coronary artery diseases (CADs) in patients with complete left bundle-branch block (LBBB). DESIGN Comparison of DSE and dipyridamole sestamibi myocardial perfusion scintigraphy (sestamibi). SETTING Tertiary-care cardiac referral center. PATIENTS Fifty-four consecutive patients (26 men; mean [+/- SD] age...