the old elamite documents are indeed rare, but from susa in the sukkalmah period there are some 550 legal documents in akkadian which provide an excellent opportunity to study elamite society and culture. the present paper edits and translates a unique and very interesting will made by gimil-adad, a man from susa in the 17th century bc. in order to provide the historical context for the proper ...

OBJECTIVE Flow-mediated dilatation (FMD) of brachial artery, renal resistive index (RRI), retina resistive index of central artery (RRICA) and carotid intima-media thickness (IMT) have been used for ultrasound assessment of cardiovascular risk as good surrogate markers of pre-clinical atherosclerosis. We investigated the interrelationship of these four parameters and examined whether an integra...

500 years of ancient Near Eastern history from the earlier second millennium BCE, including such pivotal figures as Hammurabi of Babylon, Šamši-Adad I (who conquered Aššur) and Zimrilim of Mari, has long floated in calendar time subject to rival chronological schemes up to 150+ years apart. Texts preserved on clay tablets provide much information, including some astronomical references, but des...

Background Some but not all studies have found compromised myocardial function and amyloid deposition, related or unrelated to amyloid-β pathology itself, in persons with late-onset Alzheimer’s Disease (AD). Other changes QT interval, heart rate variability, QRS voltages been described the electrocardiogram (ECG), those are consistent between studies. We explored differences several ECG measure...

Mutations in PSEN1 and PSEN2 genes, encoding presenilin 1 (PS1) and presenilin 2 (PS2), respectively, cause autosomal-dominant Alzheimer’s disease (ADAD) (1, 2). The precise mechanism by which PS1 mutations lead to AD is under active investigation. Multiple theories have been suggested to explain the role of PS1 and PS2 mutations on AD pathogenesis, including the effects on γ-secretase activity...

hydrogen bonding is considered by many to be the ‘master key’ of molecular recognition — owing to its relatively predictable strength and directionality — and plays a major role in the assembly of diverse non-covalent assemblies1. Consequently, the study and exploitation of hydrogen bonds has been central to the development of modern supramolecular chemistry. In particular, numerous applied set...

Target audience Scientists and clinicians interested in Diffusion Spectrum MRI and its methodological development Purpose To demonstrate that Diffusion Spectrum Imaging at longer diffusion times gives rise to higher anisotropy measures, as illustrated by using a stimulated echo sequence in a clinical scanner in vivo. Diffusion Spectrum MRI (DSI) [1] has become a powerful tool for non-invasive i...

Target audience Scientists and clinicians interested in acquiring Diffusion Spectrum MRI at lower b-values. Purpose To demonstrate that radial q-space sampling for Diffusion Spectrum MRI improves ODF sampling and angular resolution at lower b-values as demonstrated by computer simulations and in a clinical scanner in vivo. Diffusion Spectrum MRI (DSI) [1] has been shown to non-invasively image ...

Introduction. Multiple sclerosis (MS) is a disease with profound heterogeneity in clinical course, and neuroradiological appearance of lesions both in white and gray matter (WM, GM). Histological data demonstrate that heterogeneous pathogenic mechanisms underlie the formation of MS-like demyelinating plaques, at least in WM, and identify four major patterns of demyelination (1). This pathogenic...