A family with a history of recurring thrombosis was studied to determine if a plasma protein deficiency could account for the observed disease. Protein C levels in plasma were determined immunologically using the Laurell rocket technique. The propositus, his father, and his paternal uncle, who are severely affected, had 38-49% of normal levels of protein C antigen, whereas unaffected family mem...

Hypocupraemia with normal caeruloplasmin levels was found in a 21-month-old boy admitted to hospital because of repeated seizures and failure to thrive. He had blonde curly hair, spurring of the femora and tibiae, and mild anaemia, but his mental development, electroencephalogram, and structure of the hair on microscopical examination were normal. There was a general improvement in his conditio...

Methods A sixteen-year old male patient was admitted with painful localized swelling of the legs, high fever and cough. Medical history revealed that he had suffered from recurrent oral ulcers for 5 years, recurrent painful nodules on his legs and uveitis in the last one year. He was diagnosed with BD at another center; colchicine and eye drops were started. However, he didn’t use the pills and...

We present a molecular theory to study the adsorption of different species within pH-sensitive hydrogel nanofilms. The theoretical framework allows for a molecular-level description of all the components of the system, and it explicitly accounts for the acid-base equilibrium. We concentrate on the adsorption of hexahistidine, one of the most widely used tags in bio-related systems, particularly...

The virtually unprecedented popularity of Harriet Beecher Stowe's Uncle Tom's Cabin (1852) in the United States and England was no less marked in France, as evidenced among other things by the commercial success of the eleven French translations that were produced within the period of ten months after its original publication. This and other indications of the significance of Stowe's novel for ...

Edward Jenner's early career, as a country surgeon and apothecary for over twenty years, is obscure in contrast to the later publicity generated by his vaccination work and practice as a consulting physician in Cheltenham Spa. This is due, in part, to the meagre survival of letters and practice records from 1772, the year he commenced work in Berkeley, Gloucestershire, on completing an assistan...

C ase presentation: A healthy 32-year-old man presents for evaluation of exertional dyspnea and syn-cope. A murmur is noted, and echocardiography reveals marked sep-tal hypertrophy with a resting left ven-tricular outflow tract gradient of 68 mm Hg (online-only Data Supplement Movie I and Figure I). His father died of an MI at 38 years of age, and his paternal uncle died as the driver in a sing...

" atrophy of the skeletal muscles from congenital defect and subsequent pathological change, unassociated with any lesion of the nervous system, and characterised by progressive muscular wasting" and weakness during infancy and childhood."(l) The patient, a young Wazir Pathan, aged about 8, was brought to hospital with the history of 4 years' difficulty in walking, with frequent falls when walk...