Development of new therapeutic approach to treat leishmaniasis has become a priority. In the present study, the antileishmanial effect of β-nitrostyrenes was investigated against in vitro promastigotes and amastigotes. A series of β-nitrostyrenes have been synthesized by using Henry reaction and were evaluated for their antimicrobial activities by broth microdilution assay and in vitro antileis...

Benzimidazole and its derivatives are used in organic synthesis and they are used in evaluating new product that possesses different biological activities. This review article covers the most active benzimidazole derivatives that have shown considerable biological actions such as antimicrobial, anti-inflammatory, anticancer, anticonvulsant, antidepressant, antioxidant, radioprotective and anti-...

The neglected tropical disease, Leishmanisis, is an endemic threat of America, Africa, Asia and Southern Europe. Currently 310 million people over more than 88 countries are at risk. There are no licensed vaccines and chemotherapy is the mainstay to combat the disease which is now threatened due to the emergence of acquired drug resistance, toxicity and resurgence of HIV-VL co-infection. These ...

Purpose: To synthesize a series of novel thiazolo pyrimidine derivatives and evaluate them in vitro and in vivo for their safety and anti-leishmanial activity using BALB/c mice. Methods: Substituted pyrazolopyrimidine and pyrazolopyrazole were synthesized by reacting amino group of 2-amino-4-cyano-pyrazol]naphthalino[1,2-d]thiazole with a variety of formamide or hydrazine hydrate. The synthesiz...

This study describes an attempt to replicate experiments from the paper "Effect of BMAP-28 Antimicrobial Peptides on Leishmania major Promastigote and Amastigote Growth: Role of Leishmanolysin in Parasite Survival," which was submitted to the Reproducibility Initiative for independent validation. The cathelicidin bovine myeloid antimicrobial peptide 28 (BMAP-28) and its isomers were previously ...

The promastigote form of Leishmania donovani and Leishmania tropica, the etiologic agents of visceral and cutaneous leishmaniasis, respectively, readily parasitize unstimulated J774G8 macrophage-like cells, whereas 80-95% of the same promastigotes are killed within resident macrophages from normal BALB/c mice. This striking difference in intracellular anti-leishmanial activity correlated closel...

Leishmaniasis is one of the most diverse and complex vector-borne metazoonosis diseases[1]. The causing agent is at least 17 species[2] of obligate intracellular protozoan parasites that belong to the genus Leishmania[3]. It is transmitted to human by the bite of phlebotomine female sand flies of the genera Phlebotomus and Lutzomyia in the old and new worlds respectively[4]. The species are in ...

Objective: To investigate the biochemical capacity, and in vitro inhibitory effects of hairy roots from two cultivars Ficus carica L. (Sabz Siah) on Leishmania major promastigotes amastigotes.Methods: In roots, activity antioxidant enzymes compared to normal leaves presence some phenolic compounds comparison with fruits were investigated. The IC50 values was determined by tetrazolium-dye 3-(4, ...