Russell’s viper being one of the most venomous snake species in Asia causes significant amount bites and deaths due to neurotoxicity, coagulopathy, haemorrhage, cardiotoxicity, myotoxicity, hypotension, oedema, tissue damage convulsion. Treatment with monoclonal antibodies, anti-snake venom is only medically approved treatment available for envenomation has many limitations side effects such as...

Accidents with venomous animals are a significant cause of global morbidity and mortality. Through the evolution, these animals have used their venomous apparatus for defence and prey capture. During the adaptation process in environment, several changes have occurred in snake venoms constitution. Nowadays, it is currently known that these animals are able to accumulate a mixture of different c...

This study was done to determine whether high or low dose of anti-snake venom (ASV) is better in coagulopathy in victims of envenoming by vipers. This retrospective study was conducted on the 154 patients (Mean age ± SD, Range) of viper snake bites who were referred to the emergency ward of Razi Hospital, Ahvaz, Iran over 2 years period (2004 - 2006). According to the treatment dosage the patie...

BACKGROUND A case report of a successful recovery from paraplegia and cortical blindness following anti-venom injection for a snake bite by a common krait is reported here. CASE A 14-year old male patient was bitten by a common krait. On admission to a tertiary level hospital, he was started with antivenom serum. But the patient developed sudden respiratory distress following anaphylactic sho...

AIM At least seven North American tribes specifically mention the use of Eryngium (typically roots) as an anti-snake venom therapy. As snake envenomation is an endemic, life-threatening medical risk, is there a scientific basis for the Native American ethnomedicine? Could this be demonstrated in an assay amenable to mechanistic evaluation and high throughput screening for later isolation and po...

Snake venom has been hypothesized to have originated and diversified through a process that involves duplication of genes encoding body proteins with subsequent recruitment of the copy to the venom gland, where natural selection acts to develop or increase toxicity. However, gene duplication is known to be a rare event in vertebrate genomes, and the recruitment of duplicated genes to a novel ex...

  Objective(s): Snake venoms contain complex mixture of proteins with biological activities. Some of these proteins affect blood coagulation and platelet function in different ways. Snake venom toxin may serve as a starting material for drug design to combat several pathophysiological problems such as cardiovascular disorders. In the present study, purification of anticoagulation facto...

BACKGROUND Snake bite is a major neglected public health issue within poor communities living in the rural areas of several countries throughout the world. An estimated 2.5 million people are bitten by snakes each year and the cost and lack of efficacy of current anti-venom therapy, together with the lack of detailed knowledge about toxic components of venom and their modes of action, and the u...

Snake venom, as a natural biotoxin, is widely present in nature and can act coordination with variety of signal regulatory proteins, playing significant role the regulation tumor cell proliferation, metastasis, invasion, angiogenesis. Malignant tumors have long attracted attention medical community leading cause death humans. In this paper, we focus on reviewing progress snake venom apoptosis, ...