Paris polyphylla Smith var. yunnanensis, has been used in traditional Chinese medicine for its antibiotic and anti-inflammatory properties; in addition it has been used to cure liver cancer in particular. In this current study, β-ecdysterone (1) and three pennogenin steroidal saponins (2-4) were isolated from the EtOH extract of Paris polyphylla var. yunnanensis, and then tested for their antit...

Candida species are the cause of 60% of all mycoses in immunosuppressed individuals, leading to ∼150,000 deaths annually due to systemic infections, whereas the current antifungal therapies either have toxic side effects or are insufficiently efficient. We performed a screening of two compound libraries, the Enzo and the Institute for Molecular Medicine Finland (FIMM) oncology collection librar...

Current antifungal drugs suffer from limitations including toxicity, the emergence of resistance and decreased efficacy at low pH that are typical of human vaginal surfaces. Here, we have shown that the antipsychotic drug valproic acid (VPA) exhibited a strong antifungal activity against both sensitive and resistant Candida albicans in pH condition similar to that encountered in vagina. VPA exe...

New tetrahydrocarbazole derivatives substituted at the heteroatom (N) by non-steroidal anti-inflammatory drug (NSAIDs) were synthesized reaction of cyclohehexanon (C.H.N.) with phenyl hydrazine (P.H.Z.) to form (THCZ), where latter is reacted NSAID (Ketoprofen) via amide bond yield
 THCZ, compounds chemical structures verified by: 1H, 13C NMR and FTIR spectroscopy.
 Antifungal activit...

The plants of Carica papaya are utilised for nutritional and therapeutic purposes. phytochemical examination the leaf extract reveals all elements, including saponin, flavonoid, glycoside, alkaloid, carbohydrates, tannins, steroids. A systematic analysis was used to check extracts presence components. Free radical scavenging; wound healing; neuroprotection; diuretic; abortifacient; antifertilit...

conclusions the active compound may be a flavonoid. existence of flavonoids in tested fractions could be the important medicinal properties of m. communis leaves. further work is required to evaluate the exact effect of these biological compounds on animal model or human volunteers. results ethyl acetate and total methanolic extracts respectively had the best antifungal effects against three te...

effects of different carbon sources on growth and production of antifungal agent(s) by gymnopilus spectabilis were investigated. different carbon sources including; glucose, fructose, lactose, maltose, manitol and sucrose at the concentration of 10 g/l and slow releasing carbon sources including malt extract and soluble starch at the concentration of 2g/l were used. inhibition of spore germinat...

Compounds obtained from marine organisms have been isolated due to their anti-bacterial and antifungal activities. In this study, the antifungal activity of aqueous-methanol, methanol, chloroform and n-hexane extracts of body wall, guts and white strings of sea cucumber (Holothuria leucospilota) collected from Chabahar Bay in 100 to 2000 μg/ml concentrations is discussed. The antifunga...