BACKGROUND Despite decades of clinical use, the pharmacokinetics and the effects of acetylsalicylic acid (ASA) in critically ill patients remain ill-defined. We aimed to investigate the pharmacokinetics and the effects of different ASA formulations during critical illness. DESIGN A cross-sectional study and a randomized, parallel-group trial were performed. Critically ill patients under chron...

BACKGROUND AND PURPOSE The purpose of this study was to assess individual differences in the pharmacological effects of acetylsalicylic acid (ASA) on bleeding time as measured by in vitro platelet aggregation and to examine the consistency of responses over time. METHODS We measured template IIR bleeding time and platelet aggregation in 8 healthy male volunteers before and 2 hours after inges...

Ascorbic acid (AsA) treatment is expected to be a potential cancer therapy strategy with few side-effects that can be used alone or in combination with chemotherapy. However, the combination of AsA, a free radical scavenger, with radiation is not clearly understood; conflicting data are reported for cancer cell death. We conducted this study to determine the effect of AsA treatment combined wit...

Background: Gastrointestinal disturbances are the most common adverse effects of NSAIDs and ASA. Upper gastrointestinal bleeding (UGIB) occurs in over 2-4% of NSAIDs/ASA users. Objectives: To review patients admitted with upper gastrointestinal bleed induced by NSAIDs/ASA at the University hospital of the West Indies between January 2001 to December 2007. Methods: Patients admitted between Janu...

The inhibitory effect of NO-donating aspirin (NO-ASA) on colon cancer has been demonstrated in vivo and in vitro but its mechanism is still obscure. We investigated the effect of NO-ASA on angiogenesis. Four groups of athymic mice (N = 12) bearing subcutaneous xenotransplants of HT-29 human colon cancer cells were injected intratumorally twice a week for 3 weeks with vehicle or m-NO-ASA or p-NO...

ASA is a rare entity incidentally diagnosed during conventional transthoracic echocardiography (TTE). It is defined as the presence of redundant and mobile interatrial septal tissue extending to at least 15 mm during the cardiorespiratory cycle. The incidence of ASA has been reported at about 2% in patients undergoing TTE [1]. Patent foramen ovale (PFO) and ASA have been cited as potential risk...

Since both sodium L-ascorbate (Na-AsA) and sodium saccharin (Na-Sac) promote two-stage bladder carcinogenesis in rats, synergism of the two chemicals was investigated with special reference to the role of urinary pH and Na+ concentration. Male F344 rats were given 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine in the drinking water for 4 wk and then treated with basal diet containing 5% Na-Sac, 5%...

Objective: To determine the prognostic value of the American Society of Anesthesiologists (ASA) classification and of the main clinical pathologic variables in renal cell carcinoma (RCC) patients who underwent surgical treatment. Methods: In this international collaborative study, 376 RCC patients who underwent partial nephrectomy (PN) or radical nephrectomy (RN) during the period 1989-2009 wer...