نتایج جستجو برای: bcl 2 gene
تعداد نتایج: 3394600 فیلتر نتایج به سال:
Background: CD4 T-lymphocyte apoptosis in Human Immunodeficiency Virus infection may occur due to activation of the intrinsic apoptotic pathway or triggered via death receptors. In this study, differential expression genes involved was investigated on circulating T-lymphocytes HIV-infected patients and healthy controls. Methods: The study included 55 HIV who were (1) asymptomatic antiretroviral...
The prognostic significance of Bcl-2 protein expression and bcl-2 gene rearrangement in diffuse large cell lymphomas (DLCL) is controversial. Bcl-2 protein expression prevents apoptosis and may have an important role in clinical drug resistance. The presence of a bcl-2 gene rearrangement in de novo DLCL suggests a possible follicle center cell origin and perhaps a distinct clinical behavior mor...
the current challenges in the management of esophageal cancer are to obtain a better understanding of underlying molecular alterations to provide new treatment options. we studied the p53 and bcl-2 protein expression in esophageal carcinomas to correlate molecular alterations with clinicopathological findings. tissue samples of 37 patients with advanced esophageal carcinoma were analyzed by imm...
Colorectal cancer is one of the most common cancers in the world. Various factors are involved in the development and progression of this disease. One of these agents is cyclooxygenase-2 (COX-2). COX-2 is a product of the PTGS2 gene and converts free arachidonic acid to prostaglandins. COX-2 is not naturally expressed in most normal cells. Noticeably, the increased expression of COX-2 has been ...
We are currently conducting clinical trials of E1A gene therapy for patients with ovarian cancer. The adenovirus type 5 E1A gene suppresses growth of ovarian cancer cells that overexpress HER-2/neu (HER2) and growth of some--but not all--that express low HER2. In HER2-overexpressing cells, suppression by E1A is predominantly by down-regulation of HER2, but the mechanism in low HER2-expressing c...
Background & Objective: Vitrification is an effective mean for preserving embryos. During this process, expression of implanting and apoptotic genes changes and can affect the quality of embryos. In this study, the expressions of Bax and Bcl-2 as apoptotic genes and ErbB4 as implanting gene were investigated in vitrified and warmed embryos. Materials & Methods: In this study, six-eight w...
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