منصوره موحدین
استاد، گروه علوم تشریح، دانشکدۀ علوم پزشکی، دانشگاه تربیت مدرس، تهران، ایران
[ 1 ] - اثر شش هفته تمرین استقامتی بر بیان ژن GSK-3β در بخش حرکتی نخاع رتهای نر ویستار با نوروپاتی دیابت
گلیکوژن سنتازکیناز3 بتا، کلید تنظیمی است که خروجی بسیاری از مسیرهای پیامرسانی را تعیین میکند. مهار آن در افزایش بقای نورونی مؤثر گزارش شده است. ازاینرو پژوهش حاضر به بررسی اثر شش هفته تمرین استقامتی بر بیان ژن GSK-3β در بخش حرکتی نخاع رتهای نر ویستار با نوروپاتی دیابت میپردازد. بدین منظور 16 سر رت نر ویستار بهطور تصادفی به چهار گروه سالم کنترل، سالم تمرین، نوروپاتی کنترل و نوروپاتی تمرین...
[ 2 ] - مدل تخمدان پلی کیستیک به عنوان یک عامل افزاینده استرس اکسیداتیو در بافت تخمدان
Background and purpose: Polycystic ovary syndrome (PCOS) is one of the most common causes of infertility in modern societies. The etiology of PCOS is unknown, so a good animal model can be valuable in studying its pathogenesis and could help in making a more effective diagnosis and choosing appropriate treatments. All PCOS disorders may be the result of multiple genetic and environmental fact...
[ 3 ] - تمایز سلول های بنیادی رویانی موش به سلول های شبه عصبی
مقدمه: ویژگی های منحصر به فرد سلول های بنیادی رویانی نظیر تکثیر نامتناهی و تمایز به انواع سلول ها آن را به ابزار مناسبی برای تحقیقات زیست پزشکی در زمینه هایی مانند کاربرد درمانی برای بیماری های تحلیل برنده عصبی نظیر پارکینسون و آلزایمر تبدیل نموده است. در سال های اخیر، روش های آزمایشگاهی زیادی توسعه یافته اند که اجازه تولید نورون از سلول های پرتوان را در کشت فراهم می کند. این سلول ها اگر بر روی...
[ 4 ] - Establishment of Oxidative Stress Modeling during Spermatogonial Stem Cells Cultivation Treated with Different Doses of H2O2
Introduction: Nowadays, spermatogonial stem cells (SSCs) cultivation has been used by many researchers as an effective tool for infertility treatments. Oxidative conditions can be effective on cell proliferation and differentiation of these cells. So, the aim of this study was to establish oxidative stress model for antioxidant activity of some drugs investigation during SSCs in vitro culture. ...
[ 5 ] - In Vitro Differentiation of Neural Stem Cells into Noradrenergic-Like Cells
Neural stem cells (NSCs) as a heterogeneous multipotent and self- renewal population are found in different areas in the developing mammalian nervous system, as well as the sub-ventricular zone (SVZ) and the hippocampus of the adult brain. NSCs can give rise to neurons, astrocytes and oligodendrocytes. The aim of this study was to differentiate neural stem cells into noradrenergic–like cells in...
[ 6 ] - Effects of bilateral lesion of the locus coeruleus on the sleep-wake cycle in the rat
Introduction: Noradrenergic cells in LC participate in the process of cortical activation and behavioral arousal. The evidence suggests that locus ceoruleus (LC) plays an important role in the sleep-wake cycle. The aim of this study was stereological estimation of cavity caused by lesion and assessment of sleep stages after bilateral lesion of the LC. Materials and Methods: Male Wistar rats we...
[ 7 ] - تغییرات ژنی طی تمایز سلول‌های بنیادی اسپرماتوگونی به سلول‌های الیگوپروژنیتور
سابقه و هدف: کشت سلول‌های اسپرماتوگونی و تولید سلول‌های پر توان Embryonic Stem cells (ES like cells) ، این سلول‌ها را به عنوان منبع کافی و جدیدی برای سلول درمانی و ترمیم بیماریها از جمله بیماریهای نورو دژنراتیو پیشنهاد می‌دهد. هدف از تحقیق حاضر ارزیابی الگوی تغییرات ژنی طی تمایز سلول‌های اسپرماتوگونی به سلول‌های پیش ساز الیگودندروسیت می باشد. مواد و روشها: در این مطالعه تجربی سلول‌های اسپرمات...
[ 8 ] - Analysis of MiRNA-17 and MiRNA-146 Expression During Differentiation of Spermatogonial Stem Like Cells Derived from Mouse Bone Marrow Mesenchymal Stem Cells
In vitro derivation of germ cells from different stem cells sources has been challenging in the treatment of male infertility. MicroRNAs (miRNAs) have an essential role in gene expression at post-transcriptional level. The aim of this research was to find more about miRNA-17 and miRNA-146 expression during differentiation of spermatogonial stem cell like cells (SSC like cells) from mouse bone m...
[ 9 ] - Evaluating the Development and the Expression of Bax, Bcl-2, and ErbB4 Genes following Vitrification of Eight Cell and Blastocyst Embryos
Background & Objective: Vitrification is an effective mean for preserving embryos. During this process, expression of implanting and apoptotic genes changes and can affect the quality of embryos. In this study, the expressions of Bax and Bcl-2 as apoptotic genes and ErbB4 as implanting gene were investigated in vitrified and warmed embryos. Materials & Methods: In this study, six-eight w...
[ 10 ] - Differential gene expression by lithium chloride induction of adipose-derived stem cells into neural phenotype cells
Objective(s): Adipose-derived stem cells (ADSCs), with suitable and easy access, are multipotential cells that have the ability for differentiation into other mesodermal and transdifferentiate into neural phenotype cells. In this study, Lithium chloride (LiCl) was used for in vitro transdifferentiation of rat ADSCs into neuron-like cells (NLCs).<stro...
[ 11 ] - The Effects of Calligonum Extract and Low-intensity Ultrasound on Motility, Viability, and DNA Fragmentation of Human Frozen-Thawed Semen
Background: The study aimed to evaluate the impact of Calligonum extract and US radiation on sperm parametersof cryopreserved human semen samples.Materials and Methods: In this experimental study, twenty-five semen specimens were obtained from healthy semendonors and incubated in human tubal fluid (HTF) medium supplemented with 10% human serum albumin (HSA) for45 minutes...
[ 12 ] - Evaluation of Enkephalin-Degrading Enzymes in Sperm from Heroin-Addicted Men
Objective The aim of this study was to investigate two enkephalin-degrading enzymes, aminopeptidase N (APN/CD13) and endopeptidase (NEP/CD10), gene and protein expression levels in sperm samples of fertile and heroin-addicted men, and the correlation between their expressions and semen quality. MaterialsAndMethods This case-control study, semen collected from 24 normozoospermic healthy (as a co...
[ 13 ] - A Review on Application of Three Dimensional Culture and Testicular Scaffolds to Induction of in-Vitro Spermatogenesis
Introduction: Induction of in vitro spermatogenesis can be useful for infertility treatment in azoospermic patients and those undergoing chemotherapy. Different culture systems have been used to achieve this goal. This review study was performed with the aim to evaluate the application of 3D culture and testicular scaffolds in the establishment of in vitro spermatogenesis. In this review study...
[ 14 ] - Evaluation of different strain mice during in vitro fertilization and embryo development in response to superovulation
Background: Mice are the most commonly used animal in reproductive research and following the urgent need for these type of studies and also due to the increased interest in the ethical principle of animal rights, four various inbred and outbred strains of the laboratory mouse were evaluated to select the more efficient one for reproductive research. Materials and methods: 60 female and 16 mal...
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