A 70-year-old man with a history of high blood pressure and multiple ischemic strokes was diagnosed stage 2 chronic myelomonocytic leukemia in 2014. At diagnosis, estimated glomerular filtration rate normal (100 ml/min per 1.73 m2). Bone marrow aspiration showed 15% blasts, for which azacytidine prescribed. The patient refused the recommended treatment, hydroxyurea introduced instead.

This study was carried to identify the causes of pancytopenia and to find out the bone marrow morphology in cases of pancytopenia. It was a cross sectional study conducted over a period of two years in the Department of Pathology, Tribhuvan University Teaching Hospital. Bone marrow aspiration smears of patients fulfilling the criteria of pancytopenia were examined. The data obtained were analyz...

Malignant histiocytosis (MH) is a rare hematologic malignancy, especially in the first decade of life. The disease is clinically characterized by fever, hepatosplenomegaly, lymphadenopathy, pancytopenia and jaundice, and histologically by systemic proliferation of malignant histiocytes and hemophagocytosis. The prognosis is poor and often the diagnosis is not made before death. Because of ...

Sunitinib is an oral tyrosine kinase inhibitor which prevents tumor growth and metastatic progression. It was approved for treatment of advanced renal cell cancer, gastrointestinal stromal tumor and advanced pancreatic neuroendocrine tumors. It has several adverse reactions on multi organ systems including hematologic system. Although the neutropenia and thrombocytopenia commonly happens as Gra...

The presence of a low level of M protein in the peripheral blood <3gm/dl which is below the required cut off for the diagnosis of plasma cell myeloma is known as monoclonal gammopathy of undetermined significance (MGUS). Elevated levels of serum M protein and detection of M band on serum protein electrophoresis (SPE) can occur in chronic diseases not related to B cell disorders and not always d...

Magnetic resonance imaging (MRI) offers a global view of the bone marrow and facilitates the understanding of disease progression and the remission of hematologic malignancies. Marrow MRI is an important tool for accurate diagnosis, monitoring of disease extent, and evaluation of treatment response. MRI functions as an adjunct to bone marrow aspiration and biopsy. Furthermore, abnormal imaging ...

Sunitinib is an oral tyrosine kinase inhibitor which prevents tumor growth and metastatic progression. It was approved for treatment of advanced renal cell cancer, gastrointestinal stromal tumor and advanced pancreatic neuroendocrine tumors. It has several adverse reactions on multi organ systems including hematologic system. Although the neutropenia and thrombocytopenia commonly happens as Gra...

malignant histiocytosis (mh) is a rare hematologic malignancy, especially in the first decade of life. the disease is clinically characterized by fever, hepatosplenomegaly, lymphadenopathy, pancytopenia and jaundice, and histologically by systemic proliferation of malignant histiocytes and hemophagocytosis. the prognosis is poor and often the diagnosis is not made before death. because of the r...