background: preliminary clinical trials showed that ginger improved lipid profile in type 2 diabetes patients (t2d). this trial was carried out to determine the effect of ginger on blood lipid and lipoproteins in t2d. methods: this is a randomized, double-blind, placebo-controlled trial on 88 t2d conducted in. the patients were randomly divided into two groups of ginger (gg) and placebo (pg), t...

Objective The aim of present study was to clarify the role of the peroxisome proliferator-activated receptor (PPAR) γ Pro12Ala and C161T polymorphisms in the pathogenesis of polycystic ovary syndrome (PCOS) and their influence on lipid and lipoprotein profiles of patients. MaterialsAndMethods The present cross-sectional study consisted of 50 women with PCOS, who referred to the Kermanshah Unive...

BACKGROUND Transgenic (TG) Ca/calmodulin-dependent protein kinase II (CaMKII)delta(C) mice have heart failure and isoproterenol (ISO)-inducible arrhythmias. We hypothesized that CaMKII contributes to arrhythmias and underlying cellular events and that inhibition of CaMKII reduces cardiac arrhythmogenesis in vitro and in vivo. METHODS AND RESULTS Under baseline conditions, isolated cardiac myo...

Article history: Received on: 04/03/2013 Revised on: 19/03/2013 Accepted on: 07/04/2013 Available online: 27/04/2013 The current study aims to compare the oxidative protective effects of vitamin-P and vitamin-C on hypercholesterolemia-induced hepatic damage by high cholesterol diet (HCD) in female Wistar rats. Rats received experimental prepared HCD with or without vitamin-P or C for six consec...

Background and Objectives: Capparis decidua is a plant used in herbal medicine. This study was carried out to assess effects of C. decidua hydroalcoholic extract on blood glucose, lipid profile and leptin in male rats with high-cholesterol diets. Materials and Methods: Totally, 40 Wistar-albino male rats with 200–250 g weight were equally divided into one control (C) and three experimental gro...

We examined the effects of increased expression of proximal tubule peroxisome proliferator-activated receptor (PPAR)α in a mouse model of renal fibrosis. After 5 days of unilateral ureteral obstruction (UUO), PPARα expression was significantly reduced in kidney tissue of wild-type mice but this downregulation was attenuated in proximal tubules of PPARα transgenic (Tg) mice. When compared with w...

BACKGROUND Rimonabant, the first selective cannabinoid type 1 (CB1) receptor antagonist, improves cardiometabolic risk factors in overweight/obese patients. ADAGIO-Lipids assessed the effect of rimonabant on cardiometabolic risk factors and intraabdominal and liver fat. METHODS AND RESULTS 803 abdominally obese patients with atherogenic dyslipidemia (increased triglycerides [TG] or reduced hi...

conclusions ehp was able to both reduce ldl-ch and to significantly decrease markers of oxidative stress and lipid peroxidation induced by hyperlipidemia. therefore, this herb, as a new pharmacological component, could be used to reduce certain blood lipids, lipid peroxidation, and aminotransferase markers. materials and methods thirty-two male rats weighting 200 ± 10 g were randomly divided in...

BACKGROUND AND OBJECTIVES MC4R (melanocortin-4 receptor) gene polymorphisms have been associated with serum triglycerides (TG) in Caucasians and Japanese, but no reports are available Chinese. The purpose of this study was to find whether there was an association of rs17782313 polymorphisms at the MC4R gene with serum TG in elderly Chinese. METHODS AND STUDY DESIGN 2,012 over 40 years partici...