Received Nov 9, 1995; Accepted Dec 6, 1995 Correspondence to: J. L. Mattsson, The Dow Chemical Company, Health and Environmental Sciences, 1803 Building, Washington Street, Midland, MI 48674, USA *Presented as Con argument in a debate , "Exposure To Synthetic Chemicals Is More Hazardous Than Exposure To Natural Chemi cals." International Congress of Toxicology VII, July 2-6, 1995, Seattle, Wash...

The study of combinations of anticancer chemi cals has for its objective the selection of combina tions which would produce synergistic therapeutic effects in animal and human tumors without an in creased toxicity to the host. It could be expected, also, that, when two or more anticancer chemicals are used simultaneously for the treatment of tu mors, there will be less chance for appearance of ...

BACKGROUND The caspase-associated recruitment domain-containing protein (CARP) is expressed in almost all tissues. Recently, the tumor-suppressive function of CARP was discovered and attracted increasing attention. This study aimed to investigate the role of CARP in the carcinogenesis of human gastric carcinoma. METHODOLOGY/PRINCIPAL FINDINGS Compared with normal gastric tissue, the downregul...

Despite an increasing incidence of human breast cancer, its etiology remains unknown. Since some environmental chemicals are stored in human breast fat and are rodent mammary carcinogens, determining the genotoxic potential of environmental agents in this key target tissue is important. An assay was developed for detecting genotoxic activity, as unscheduled DNA synthesis (UDS), induced by chemi...

We have isolated two Chinese hamster ovary cell lines, designated ADR-4 and ADR-5, which exhibit hypersensitivity to intercalating agents and epipodophyllotoxins. These drugs are thought to exert their cytotoxicity via an interaction with the enzyme topoisomerase II. However, there is no apparent change in the level or catalytic activity of topoisomerase II in the mutant cells. Drug sensitivity...

it more susceptible to leaching (Albus and Knighton, 1998). Higher moisture contents will also raise microbial Groundwater and surface water are significant resources for rural activity including mineralization (Skopp et al., 1990). water supplies, and certain agricultural practices may have substantial effects on these resources. An 11-yr study was started in 1989 near The increase in minerali...

The purpose of this study was to determine if miners were at risk from exposures to chemicals used in the mining industry and determine the nature and sources of the illnesses and injuries. The U.S. Mine Safety and Health Administration’s (MSHA) employment and accident, in­ jury and illness database was reviewed. There were 2,705 cases of chemical-related injuries and illnesses reported from 19...