The nuclear modulation effect in pulsed EPR spectroscopy was used to probe the metal-protein bonds in Cu(II)=transferrin complexes as a function of pH. In preparations in equilibrium with air at pH 4.8 no modulation features other than those attributable to protons were observed, in keeping with conventional EPR studies indicating that at this pH only nonspecific binding takes place (Zweier, J....

Both calcium-containing and noncalcium-containing phosphate binders can increase gastrointestinal calcium absorption. Previously, we observed that lanthanum carbonate administration to rats with renal failure is not associated with increased calciuria. Additionally, lanthanum carbonate treatment in dialysis patients has been associated with a less pronounced initial decrease in serum parathyroi...

Carbonate mud is a major constituent of recent marine carbonate sediments and of ancient limestones, which contain unique records of changes in ocean chemistry and climate shifts in the geological past. However, the origin of carbonate mud is controversial and often problematic to resolve. Here we show that tropical marine fish produce and excrete various forms of precipitated (nonskeletal) cal...

This work explores the effect of additives on the pouring temperature in a waterworks and industrial calcium fluoride sludge co-melting system. Two kinds of sludge were mixed in various ratios to find a mixing ratio at which the operating temperature for subsequent additive tests was relatively low. Various proportions of either sodium carbonate (Na2CO3) or potassium carbonate (K2CO3) reagent w...

BACKGROUND Control of serum phosphate over the long term is essential in patients with end-stage renal disease. Six-month and 2-year extensions to a 6-month study evaluated the long-term safety, tolerability and efficacy of the new phosphate binder lanthanum carbonate. METHODS Patients who participated in a 6-month, randomized trial comparing lanthanum carbonate with calcium carbonate were el...

BACKGROUND Lanthanum carbonate (FOSRENOL®) is an effective, well-tolerated phosphate binder. The ability of lanthanum to reduce serum phosphorus levels to ≤5.5 mg/dL in patients with end-stage renal disease (ESRD) was assessed in a clinical practice setting. METHODS A 16-week, phase IV study enrolled 2763 patients at 223 US sites to evaluate the efficacy of lanthanum carbonate in controlling ...

THIS PAPER REPORTS A METHOD for determining carbonate in carbonate-containing solids by means of the Van Slyke-Neill manometric apparatus, which is widely used for the determination of carbon dioxide in biologic fluids. The method is rapid, convenient, and quantitative, and it makes possible the determination of carbonate in solids by the average clinical laboratory without the purchase of addi...

Through field investigation and experimental analysis, the forms, contents distribution of heavy metals (Zn, Pb, Cu, Cd, Ni, Cr) in rhizosphere non-rhizosphere soils Miscanthus floridulus growing everywhere Tielongwei mine pond (sample plot 1), Caoduikeng tailings 2), Donghua 3) Small 4) Dabaoshan, Guangdong Province were studied. The results showed that main forms distributions are basically s...

Neutron diffraction with isotopic substitution has been used to investigate the liquid structures of propylene carbonate and glycerol carbonate. C-HO[double bond, length as m-dash]C hydrogen-bonding motifs dominate the local structure of propylene carbonate, giving rise to the formation of head-to-tail correlated chains of molecules. In contrast, glycerol carbonate exhibits a more disordered st...

The in vivo binding of nickel to chromatin, nucleic acids, and nuclear proteins from rat kidney and liver was investigated. Evidence is presented for the direct interaction of nickel with chromatin from rat tissues following i.p. injection of nickel carbonate. A gentle DNA isolation procedure was developed and used to isolate nickel-bound whole chromatin, DNA + histone octamer complex (polynucl...