Background: Sjögren’s syndrome (SS) is an autoimmune inflammatory disease that primarily affects the exocrine glands, leading to glandular dysfunction. The hallmark symptoms of SS are dry eyes and mouth, compromising quality life patients decreasing their capacity perform daily activities. Objective: This study aims evaluate efficacy herbal formula SS-1 for its potential therapeutic benefits wi...

Chimeric antigen receptors redirect T cells to surface antigens. Discovery and validation of appropriate target antigens expand the possible indications for chimeric-antigen receptor (CAR)-T cells. B-cell maturation antigen (BCMA) is expressed only on mature B cells and plasma cells and promotes their survival. BCMA is a promising target for CAR-T cells in multiple myeloma.

literature review shows that hepatitis c infection may increase the risk of non-hodgkin lymphoma. reactivation of hepatitis b infection has been reported in patients with hairy cell leukemia after chemotherapy and/or splenectomy. we present hepatitis b surface (hbs) antigenemia and concurrent hepatitis c virus (hcv) seropositivity in a case of hairy cell leukemia. key words: hairy cell leukemia...

background: dendritic cells (dc) induce tumor or pathogen-specific t cell responses in humans. several laboratories have developed culture systems, including maturation factors for human dc from peripheral blood monocytes. we comprehensively compared standard maturation stimulus, an autologous monocyte-conditioned medium (mcm), with heparin for their ability to promote uniformly mature dc that ...

the use of ovarian stimulation for infertility treatment is associated with side effects of ovarian hyperstimulation syndrome (ohss) and potential cancer risk. this is also true in high risk women such as those polycystic with ovary (pco) and polycystic ovarian syndrome (pcos). in vitro maturation (ivm) of oocytes was primarily developed to make ivf safe for women with pco and at high risk of o...

Antigen specific B cells undergo a process termed affinity maturation in the germinal centers of secondary lymphoid organs where B cells with high affinity receptors are selected to mature into antibody-producing cells or to the memory B cell pool. It is known that B cell antigen receptor (BCR) signaling plays pivotal role in this selection process. Calcium influx is an essential component of B...

Abstract Accumulating data have highlighted the role of monocytes/macrophages in immune escape by generating immunologically “cold” tumors that do not respond to immunotherapy. CD244 (SLAMF4, 2B4), a member signaling lymphocyte activation molecule family, is expressed on myeloid cells, but its precise has been elucidated. Using monocyte lineage-specific CD244-deficient micechallenged with B16F1...

A hallmark of T cell-dependent immune responses is the progressive increase in the ability of serum antibodies to bind antigen and provide immune protection. Affinity maturation of the antibody response is thought to be connected with the preferential survival of germinal centre (GC) B cells that have acquired increased affinity for antigen via somatic hypermutation of their immunoglobulin gene...

CONTEXT AND OBJECTIVE Dendritic cell maturation is considered essential for starting an immune response. The CD83 antigen is an important marker of dendritic cell maturation. The objectives here were to analyze CD83 antigen expression in human breast fibroadenoma and breast tissue adjacent to the lesion and to identify clinical factors that might influence this expression. DESIGN AND SETTING ...