Medical Memoranda MEDBYRNAL 545 Gardner (1953) and Kriss et al. (1955) reported certain side-effects after administration of cobalt even for short periods. These effects included nausea, vomiting, damage to the eighth cranial nerve nuclei, thyroid hyperplasia and myxoedema, and congestive heart failure (Goodman and Gillman, 1965). The case described above showed some of these toxic effects. The...

An individual approach in the cobalt-induced stress dependently hypoxic states properties was analyzed. Effects of cobalt (Co) chloride treatment (30 mg kg bw, 3 h) on metals content (Na, K, Ca, Fe, Zn, Mn, Mg, Co, Cd and Pb) in femur, plasma, and liver Wistar rats with individual resistance to hypoxia (low resistance LR and high resistance HR) were studied. Effects of cobalt chloride were medi...

OBJECTIVES Evaluation of the allergenic properties of the metal knee or hip joint implants 24 months post surgery and assessment of the relation between allergy to metals and metal implants failure. MATERIALS AND METHODS The study was conducted in two stages. Stage I (pre-implantation) - 60 patients scheduled for arthroplasty surgery. Personal interview, dermatological examination and patch t...

It has been reported that cardiomyopathy was the main cause of death in Quebec, Omaha and Minneapolis beer-drinkers, who drank a large quantity of beer containing cobalt chloride as a stabilizer of foam. Myocardial biopsies of Quebec beerdrinkers1) revealed an increase of glycogen granules and accumulation of lipid droplets or vacuoles. Similar findings were noted in the cardiac muscles of rabb...

Drug resistance is a major factor for the limited efficacy of chemotherapy in gastric cancer treatment. Hypoxia-inducible factor-1α (HIF-1α), a central transcriptional factor in hypoxia, is suggested to participate in the resistance. Here, we identified a hypoxia-mimic (cobalt chloride) sensitive gastric cell line BGC-823 to explore whether diosgenin, an aglycone of steroidal saponins, can inhi...

Assay of the enzyme ferrochelatase in marrow, liver, spleen, and red cells has been employed to assess the extent of erythropoietic stimulation in animals bearing the Walker 256 carcinosarcoma and in rats treated by administration of phenylhydrazine, cobalt chloride, human urinary erythropoietin, or chronic blood loss. In all instances, the spleen sustains the most marked increase of ferrochela...

Sphere-like shaped cobalt oxide nanoparticles (Co3O4) were synthesized by a simple wet chemical method using cobalt chloride as precursor and cetyl trimethylammonium bromide (CTAB) as surfactant. Their structural and surface morphologial properties were characterized by high resolution transmission electron microscopy (HRTEM), field emission scanning electron microscopy (FESEM) and X-ray diffra...

Tungsten trioxide (WO3) nanostructures were synthesized by hydrothermal method using sodium tungstate (Na2WO4 2H2O) alone as starting material, and sodium tungstate in presence of ferrous ammonium sulfate [(NH4)2 Fe(SO4)2 6H2O] or cobalt chloride (CoCl2 6H2O) as structure-directing agents. Orthorhombic WO3 having a rectangular slab-like morphology was obtained when Na2WO4 2H2O was used alone. W...

In this work, separation of cobalt(II) over lithium(I) ions from aqueous chloride solutions by synergistic solvent extraction (SX) has been studied. A synergistic mixture of commercial extractants such as bis(2,4,4-trimethylpentyl)phosphinic acid (Cyanex 272) and tributyl phosphate (TBP) in kerosene was used as a selective extractant. The investigations were first performed to select optimal co...