To determine the effects of cobalt chloride on human submandibular gland cells, HSG cells were exposed to various concentrations of cobalt chloride. Cobalt chloride induced cytotoxicity and cell death in HSG cells as determined by phase-contrast microscopy and WST-1 cell viability assay. By using the Hoechst 33342 staining, marked nuclear condensation and fragmentation of chromatin were observe...

Background: Cobalt (Co) is an essential trace element for mammals required for the synthesis of vitamin B12. It is not a cumulative toxin but chronic exposure induces negative effects on the organism. It was proven that cobalt passes via placenta appearing in the fetal blood and amniotic fluid and it is shown to possess an embryotoxic effect. Also, chromium (Cr) is recognized as a trace element...

Background: Cobalt (Co) is an essential trace element for mammals required for the synthesis of vitamin B12. It is not a cumulative toxin but chronic exposure induces negative effects on the organism. It was proven that cobalt passes via placenta appearing in the fetal blood and amniotic fluid and it is shown to possess an embryotoxic effect. Also, chromium (Cr) is recognized as a trace element...

1. We tested whether pretreatment of reagents known to induce hypoxia-inducible factor-1 (HIF-1) may confer chemoresistance against cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) to rat C6 glioma cells. We also studied which cytotoxic mechanism(s) of chloroethylnitrosoureas could be neutralized by cobalt preconditioning. 2. Preconditioning of rat C6 glioma cells with cobalt chlorid...

OBJECTIVES The inspiration of cobalt containing dust leads to various respiratory symptoms, including asthma and interstitial lung disease. Occupational asthma caused by cobalt chloride has been diagnosed in a 35-year-old patient, who worked as a diamond polishing disc former. The patient presented a 2-year history of dyspnea, cough and symptoms of rhinitis. MATERIALS AND METHODS The patient ...

16 Recent reports from Australia suggest that cobalt chloride is being used in racehorses 17 competing in New South Wales and Victoria. Although these are the first such reports, it is 18 suspected that cobalt chloride may have been used illegally for some time. Cobalt chloride is 19 a well-established hypoxia mimetic that is used experimentally to stabilise hypoxia-inducible 20 factor 1  (HIF...

Microalgae Chlorella Vulgaris is enriched in vitamin B12 and cobalt ion which is positioned in the center of the vitamin molecule. This study aimed to investigate how different concentrations of cobalt chloride salt affected the vitamin B12 production by utilizing CO2  gas, to assess C. vulgaris biomass. Therefore, Bold’s basal medium used as the medium and  0.5, 1....

Cobalt (Co2+) is required as an essential trace element to a variety of metabolic functions such as the synthesis of vitamin B12 in mammals. It was proven that cobalt passes through the placenta to the fetus. Cobalt possesses toxic effect on embryo. Also, Chromium (Cr3+) as an essential element for both animal and human nutrition has antioxidative capacity. In this study we examined the effects...

Tumor cells are often found under hypoxic conditions due to the rapid outgrowth of their vascular supply, and, in order to survive hypoxia, these cells induce numerous signaling factors. Akt is an important kinase in cell survival, and its activity is regulated by the upstream phosphoinositide 3-kinase (PI3K) and receptor tyrosine kinases (RTKs). In this study, we examined Akt activation and RT...