PERFORM-K was a cross-sectional observational study that investigated functional disability, productivity and quality of life in MDD outpatients in South Korea, and the associations of these with depressive symptoms, perceived cognitive dysfunction and other factors. A total of 312 outpatients who started antidepressant monotherapy underwent a single study interview. Physicians and patients ass...

aim and background: schemas are cognitive patterns that have a major impact on the perception and behavior. therefore, it is necessary to investigate their role in determining and changing health related behaviors in ms patients. the purpose of this study is to investigate the mediating effect of illness perception on the relationship between early maladaptive schemas in the domain of rejection...

In individuals with multiple sclerosis, physical and cognitive disability progression are clinical and pathophysiological hallmarks of the disease. Despite shortcomings, particularly in capturing cognitive deficits, the Expanded Disability Status Scale is the assessment of disability progression most widely used in clinical trials. Here, we review treatment effects on disability that have been ...

Background High cognitive reserve (CR) has been related to a decreased dementia risk, but the association between CR and survival with independence is unknown. We examined whether lifelong accumulation associated disability-free explored extent which function mediates this association. Method Within Rush Memory Aging Project, 1,633 dementia- participants (mean age: 79.3 years) were followed ann...

OBJECTIVES To determine whether vascular and demographic factors predict worsening disability up to 8 years after lacunar stroke. METHODS SPS3 (Secondary Prevention of Small Subcortical Strokes) was a clinical trial in lacunar stroke patients with annual assessment of disability using the Older Americans Resources and Survey instrumental activities of daily living (IADL) scale (range 0-14). G...

730 www.thelancet.com Vol 387 February 20, 2016 The longing for longevity without decrepitude is ancient. Homer tells us that to live out his days with Penelope, Odysseus rejected immortality. Later restored to family and kingdom, the gods’ further favour included being able to look forward to an unenfeebled old age. So how goes our longing now? Around the world, although life expectancy is inc...

The present research tested whether children's disability representations are influenced by cultural variables (e.g., social activities, parent education, custom complex variables) or by cognitive constraints. Four questionnaires were administered to a sample of 76 primary school aged children and one of their parents (n = 152). Questionnaires included both open-ended and closed-ended questions...

BACKGROUND Evaluating the long term benefit of therapy in multiple sclerosis (MS) is challenging. Although randomised controlled trials (RCTs) demonstrate therapeutic benefits on short term outcomes, the relationship between these outcomes and late disability is not established. METHODS In a patient cohort from the pivotal interferon β-1b trial, the value of clinical and MRI measures were ana...