Collagens are often considered a metazoan hallmark, with the fibril-forming fibrillar collagens present from sponges to human. From evolutionary studies, three fibrillar collagen clades (named A, B, and C) have been defined and shown to be present in mammals, whereas the emergence of the A and B clades predates the protostome/deuterostome split. Moreover, several C clade fibrillar collagen chai...

Extracellular matrix (ECM) proteins can modify immune reactions, e.g. by sequestering or displaying growth factors and by interacting with immune and glial cells. Here we quantified by quantitative polymerase chain reaction (qPCR) expression of 50 ECM components and 34 ECM degrading enzymes in multiple sclerosis (MS) active and inactive white matter lesions. COL1A1, COL3A1, COL5A1 and COL5A2 ch...

Collagens, the most abundant proteins in animals, also occur in some recently described nucleocytoplasmic large DNA viruses such as Mimiviridae, which replicate in amoebae. To clarify the impact of viral collagens on the immune response of animals exposed to Mimiviridae, we have investigated the localization of collagens in Acanthamoeba polyphaga mimivirus particles and the response of mice to ...

Small amounts of components which react as hexoses are present in highly purified collagens. Grassmann et al. (1) have shown that the hexose units are probably attached to the protein backbone in collagen through a glycosidic linkage. From acid hydrolysates of collagens of a number of species, Gross, Dumsha, and Glazer (2) isolated n-glucose and n-galactose. Certain of the collagens also contai...

CONTENTS ORIGINAL PUBLICATIONS 5 ABBREVIATION 6 ABSTRACT 7 INTRODUCTION 9 REVIEW OF THE LITERATURE 11 WOUND HEALING 11 Blood clot formation 12 Inflammation 12 Epithelialization 13 Neovascularization 13 Formation of Granulation Tissue 15 Matrix Remodeling 16 Viscose cellulose sponges as a wound healing model 17 EXTRACELLULAR MATRIX 18 Collagens 18 Structure and biosynthesis of collagens 21 Fibri...

In humans, vocal tissue stiffness increases with age, suggesting a possible contribution of age-associated variations in vocal fold collagen turnover to voice senescence. The underlying mechanisms remain to be explored. With the use of reverse-transcriptase polymerase chain reaction (RT-PCR), collagen subtypes expressed in rat vocal folds were determined, and messenger RNA (mRNA) levels of coll...