In order to achieve prolong corneal contact time of norfloxacin(NFX) for treatment of extra ocular diseases, a pH triggered nanoparticulate in situ gelling system was designed to explore dual advantage of nanoparticles and in situ gelling system, for its ocular delivery. NFX loaded nanocarriers were developed by ionotropic gelation technique using chitosan as a matrix forming polymer, cross-lin...

The trigeminal nerve gives rise to the corneal subbasal system, which plays a crucial role in sensations of touch, pain, and temperature ocular healing processes. Technological advancements instruments, particular vivo confocal microscopy aethesiometry, have allowed for structural functional evaluation nerves health disease. Through application these technologies humans animal models, abnormali...

BACKGROUND The introduction of corneal cross-linking (CXL) with ultraviolet-A (UVA) and Riboflavin photosensitizer (Vit B2) from Seiler et al., revolutionized the treatment of Keratoconus and other corneal ectatic diseases. Today, the commonly known epithelium off Dresden protocol is in clinical use for the last 15 years with great success and regarded by many as the golden standard. METHODS ...