نتایج جستجو برای: cryopreservation of human ovarian tissue

تعداد نتایج: 21355779  

2015
Won-Jun Choi Jin-Sook Seok In-Young Choi Ji-Kwon Park Jeong-Kyu Shin Soon-Ae Lee Won-Young Paik Jong-Hak Lee

OBJECTIVE Revascularization is critical for successful ovarian tissue transplantation. Vascular endothelial growth factor (VEGF) and angiopoietin-2 (angpt-2) are the principal mediators of neovascularization. This study was designed to assess VEGF and angpt-2 levels in cryopreserved ovarian tissue after heterotopic autotransplantation. METHODS Ovarian tissues harvested from ICR mice at 5 to 6...

A Najafi E Asadi, Z Raisi Dehkordi

Background Fertility preservation is an important part of scientific study in the field of reproductive medicine. Ovarian cryopreservation and in vitro follicles culture provide option for fertility conservation in older women or cancer patients. Basic fibroblast growth factor (bFGF) or FGF-2, is member of fibroblast growth factors family which play critical roles in cell migration proliferatio...

Journal: :Human reproduction 2014
R Imbert F Moffa S Tsepelidis P Simon A Delbaere F Devreker J Dechene A Ferster I Veys M Fastrez Y Englert I Demeestere

STUDY QUESTION Do the benefits of ovarian tissue cryopreservation outweigh the risks for patients seeking to preserve fertility before gonadotoxic treatment in various indications? SUMMARY ANSWER In >90% of the patients undergoing cryopreservation of ovarian tissue, oncological treatment was associated with a reduced ovarian reserve and in 30% of patients, premature ovarian failure (POF) occu...

2013
Caterina Wiedemann Jennifer Zahmel Katarina Jewgenow

BACKGROUND Cryopreservation of ovarian tissue has the potential to preserve female germ cells of endangered mammals. In the present study, a freezing protocol successfully used for human tissue, was adapted for preserving ovarian tissue of domestic and non-domestic felids. Ovaries from non-domestic felid species were obtained from seven freshly euthanized and two recently deceased wild felids k...

Akhondi MM Behzadi B Borjian S Heidari B Naderi MM, Sarvari A Shirazi A

Background: With all the recent advances in cancer treatments, many young cancer patients find themselves facing the prospect of losing their fertility after aggressive chemotherapy or radiotherapy. Cryopreservation of ovarian cortical tissue has emerged as a potential option to restore fertility in these young women. Materials and Methods: Because autotransplantation of cryopreserved ovarian c...

2015
Nicolette G. Alkema Tushar Tomar Evelien W. Duiker Gert Jan Meersma Harry Klip Ate G. J. van der Zee G. Bea A. Wisman Steven de Jong

Using patient-derived xenografts (PDXs) for preclinical cancer research demands proper storage of tumour material to facilitate logistics and to reduce the number of animals needed. We successfully established 45 subcutaneous ovarian cancer PDXs, reflecting all histological subtypes, with an overall take rate of 68%. Corresponding cells from mouse replaced human tumour stromal and endothelial c...

2012
R. Fabbri R. Vicenti M. Macciocca G. Pasquinelli M. Lima I. Parazza V. Magnani S. Venturoli

Cancer treatments improve the survival rate of children and adolescents; however chemo- and radiotherapy result in gonadal damage leading to acute ovarian failure and sterility. Ovarian tissue cryopreservation allows long-term storage of primordial follicles and represents the only possibility of preserving the potential fertility in prepubertal girls. The aim of the present study is to describ...

Journal: :The oncologist 2007
Isabelle Demeestere Philippe Simon Serena Emiliani Anne Delbaere Yvon Englert

Cryopreservation of ovarian tissue is now offered as an experimental procedure to preserve the fertility of young patients with a high risk for premature ovarian failure resulting from cancer therapy. This is the only available option to preserve the fertility of prepubertal patients treated with gonadotoxic chemotherapy. At present, thousands of patients all over the world have undergone this ...

2011
Giovanna Fasano Federica Moffa Julie Dechène Yvon Englert Isabelle Demeestere

BACKGROUND In the past few years, cryopreservation of ovarian tissue has become an established procedure proposed in many centers around the world and transplantation has successfully resulted in full-term pregnancies and deliveries in human. This prospective study aims to evaluate the feasibility of vitrifying in vitro matured oocytes (IVM) isolated at the time of ovarian tissue cryopreservati...

Journal: :Biology of reproduction 2010
Susan L Barrett Lonnie D Shea Teresa K Woodruff

Cryopreservation of oocytes and embryos is commonly used to preserve fertility. However, women undergoing cancer treatment may not have the time or may not be good candidates for these options. Ovarian cortical tissue cryopreservation and subsequent tissue transplant has been proven successful yet inefficient in preserving larger secondary follicles, and is not recommended as a fertility preser...

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