Current standard of treatment for chronic hepatitis C virus infection requires the use of pegylated interferon plus ribavirin. Treatment with these two agents has been associated with numerous side effects, which frequently include dermatologic eruptions. We report a cutaneous eruption associated with interferon having clinical presentation of erythema annulare centrifugum. The eruption occurre...

Lenalidomide is an immunomodulatory drug (IMiD) used principally in the treatment of multiple myeloma (MM), myelodysplastic syndromes (MS) and amyloidosis. Adverse reactions related to lenalidomide include myelosuppression (mainly neutropenia but also thrombocytopenia), gastrointestinal problems, skin eruption, atrial fibrillation and asthenia, decreased peripheral blood stem cell yield during ...

A 90-year-old woman was seen with a generalized bullous eruption. She did not remember suŒering from similar lesions previously. She had hypertension treated for more than one year with hydrochlorothiazide and valsartan (Co-diovanâ ). Six weeks before the start of cutaneous lesions, nimodipine (Nimotopâ ) and ginko biloba (Tanakeneâ ) had been added to her therapy. In October 2000 she received ...

Twenty nine patients with genital fixed drug eruptions were studied during one year. In 15 the genitalia were exclusively affected, whereas the other 14 had cutaneous lesions in addition. It was striking that those whose lesions were exclusively genital reported for consultation much earlier. Drug history was the mainstay of diagnosis. Provocation tests with graded doses of the suspected drug(s...

Fixed drug eruptions due to ibuprofen have rarely been reported. Two days after treatment with ibuprofen, a 61-year-old woman developed erythema and pain affecting the tongue and oral mucosa. Two months later, the patient started ibuprofen and erythromycin for a catarrhal episode with reappearance of the same lesions in the oral mucosa 24 hours later. Furthermore, two new erythematosus-violaceo...

Acute localized exanthematous pustulosis is a localized variant of acute generalized exanthematous pustulosis, which is characterized by the eruption of multiple scattered pustules following drug administration. A 72-year-old woman presented with multiple erythematous pustules on her face, which had appeared two days after using cefoperazone and sodium sulbactam. Histopathological findings show...

Methods A retrospective chart review of all cases with suspected FDE seen in National Skin Centre, Singapore between 2008 and 2012 was performed. All cases were classified into whether the diagnosis of FDE was definite, probable, possible or unlikely based on WHO-UMC Causality Assessment criteria. Patients were classified as probable FDE if there was typical cutaneous eruption which was tempora...