Pluripotent stem cells can be differentiated into 3D retinal organoids, with major cell types self-patterning into a polarized, laminated architecture. In static cultures, organoid development may be hindered by limitations in diffusion of oxygen and nutrients. Herein, we report a bioprocess using rotating-wall vessel (RWV) bioreactors to culture retinal organoids derived from mouse pluripotent...

We construct a classical solution of vacuum string field theory (VSFT) and study whether it represents the perturbative open string vacuum. Our solution is given as a squeezed state in the Siegel gauge, and it fixes the arbitrary coefficients in the BRST operator in VSFT. We identify the tachyon and massless vector states as fluctuation modes around the classical solution. The tachyon mass squa...

A recent publication indicated that the patient anatomical feature (PAF) model was capable of predicting optimal objectives based on past experience. In this study, the benefits of IMRT optimization using PAF-predicted objectives as guidance for prostate were evaluated. Three different optimization methods were compared.1) Expert Plan: Ten prostate cases (16 plans) were planned by an expert pla...

In numerical control (NC)-based machining, NC data-based tool paths affect both quality and productivity. data are generated according to cutting conditions. However, causing excessive load can accelerate wear even result in damage. the opposite case, increasing machining time influence surface from perspective of dynamics machine tool–material–tool combination. There have been a lot studies on...