Four types of chemosignal donors were used: adult intact males, grouped adult intact females, pregnant females and lactating females. A daily dose of 0.001 ml urine was sufficient to produce the same degree of acceleration or delay known to occur with whole urine from each donor type. With 0.00001 ml the age of puberty did not differ from that of water-treated controls for any of the treatments...

Pubertal maturation, growth, and gonadal function were assessed in 13 boys with acute lymphoblastic leukaemia who had received direct testicular irradiation three to nine years earlier as treatment for testicular relapse or prophylaxis against this complication. Six boys had reached Tanner stage III-V puberty, five of whom had normal growth velocities and bone ages equivalent to chronological a...

background: adolescence is a critical stage of growth and development. that is associated with changes in body shape and appearance. issues such as irregular menstrual periods, amenorrhea, and menstrual cycle are major issues in women's health. the purpose of this study was to examine the determinants of physical puberty health based on the health belief model (hbm) among female adolescents.   ...

background: adolescence is a critical stage of growth and development. that is associated with changes in body shape and appearance. issues such as irregular menstrual periods, amenorrhea, and menstrual cycle are major issues in women's health. the purpose of this study was to examine the determinants of physical puberty health based on the health belief model (hbm) among female adolescent...

BACKGROUND Constitutional delay of growth and puberty (CDGP) is a variation of the onset and timing of pubertal development without a defined endocrine abnormality. Recently published studies indicate that leptin and ghrelin play a role in puberty initiation and progress. They have been implicated in regulation of GnRH secretion, with ghrelin having inhibitory and leptin, facilitatory effects. ...

BACKGROUND Puberty onset is a complex, organized biological process with multilevel regulation, and its physiopathological mechanisms are yet to be elucidated. RFRP-3, the mammalian ortholog to gonadotropin-inhibitory hormone, is implicated in inhibiting the synthesis and release of gonadotropin in mammals. However, it is unclear whether RFRP-3 participates in regulating pubertal development. ...

Small for gestational age (SGA) children are more prone to have precocious pubarche and exaggerated precocious adrenarche, an earlier onset of pubertal development and menarche, and faster progression of puberty than children born of appropriate for gestational age (AGA) size. The majority of studies investigating the onset of puberty in children born SGA and AGA established that, although pube...

Previous Investigators have presented data which suggest an interaction of the adrenal glands with the hypothalamic-pituitary-ovarian axis In the adult rat. The question arises as to what role, If any, these secretions play In the first ovulation and in the developmental period preceding It. Therefore the role of the developing adrenal glands ln the maturation of the hypothalamic-pituitary-ovar...