Background: The poor permeability of the plasma and nuclear membranes to DNA plasmids are two major barriers for the development of these therapeutic molecules. Therefore, success in gene therapy approaches depends on the development of efficient and safe non-viral delivery systems. Objectives: The aim of this study was to investigate the in vitro delivery of plasmid DNA encoding HPV16 E7 gene...

nanotechnology is the study of manipulating matter on an atomic and molecular scale. generally, nanotechnology deals with developing materials, devices, or other structures possessing at least one dimension size from 1 to 100 nanometers .  carbon nanotubes have great potentials for novel applications in industry, drug delivery system and many other uses. in this work after purification, multiwa...

The aim of writing this review on gastro retentive and floating drug delivery system was to compile the new literature with the principle mechanism of floatation to acquired gastric retention. Various attempts have been made to develop gastroretentive delivery systems such as high density system, swelling, floating system. In floating multiple unit and single unit system are design and their cl...

Transcutaneous immunization refers to the topical application of antigens onto the epidermis. Transcutaneous immunization targeting the Langerhans cells of the skin has received much attention due to its safe, needle-free, and noninvasive antigen delivery. The skin has important immunological functions with unique roles for antigen-presenting cells such as epidermal Langerhans cells and dermal ...

Pulmonary drug delivery is primarily use to treat conditions of the airways, delivering locally acting drugs directly to their site of action. These routes of drug delivery may give the advantages like small amount of drug, less adverse reaction and rapid onset of action. The human respiratory system is complicated organ system these system consist of two reagions conducting airways and respira...

Controlled release drug delivery systems provide uniform concentration of drug to the absorption site and thus allow the maintenance of plasma concentration within the therapeutic range which minimizes not only the side effects but also the frequency of administration. Oral Sustained release (SR) products provide an advantage over conventional dosage forms by optimizing properties of drugs in s...

Nanotechnology is an emerging technology seeking to exploit distinct technological advances of controlling the structure of materials at a reduced dimensional scale approaching individual molecules and their organised aggregates or supramolecular structures. These technological innovations, referred to as nanomedicines by the National Institutes of Health (Bethesda, MD, USA), have the potential...