A 3-year-old, female Spitz, was presented due to lack of response to therapies with a 6-month history of skin lesions characterized by diffuse erythema and scaling on the dorsal trunk. Physical examination revealed the dog was active and healthy. Skin culture isolated no fungus. Histological examination of skin biopsy specimens revealed interface dermatitis with hydropic degeneration of the bas...

The integument consists of the skin, and a variety of skin derivatives. In humans, these include hair, nails and several types of glands. In other mammals, these cutaneous appendages include scales, quills, spines, claws, hooves, and horns. The skin consists of a superficial epithelial component, the epidermis, and an underlying layer of connective tissue, the dermis. Together these layers cove...

Introduction: The process of wound healing is best represented by an uninfected surgical wound. It characterized the formation granulation tissue, with migration and proliferation fibroblasts, neoangiogenesis production extracellular matrix. Granulation tissue gradually replaced scar made up connective and, in most cases - ended three or four weeks. whole takes about six weeks a newly formed ha...

In postnatal skin the transcription factor Sox2 is expressed in the dermal papilla (DP) of guard/awl/auchene hair follicles and by mechanosensory Merkel cells in the touch domes of guard hairs. To investigate the consequences of Sox2 ablation in skin we deleted Sox2 in DP cells via Blimp1Cre and in Merkel cells via K14Cre. Loss of Sox2 from the DP did not inhibit hair follicle morphogenesis or ...

argas reflexus is considered obligate blood feeder that may cause skin redness and local swelling. for histopathological evaluation of biting site, pigeons were used as natural host species in this study. adult ticks were collected from urmia, north-west of iran and kept in a desiccator before their use in the experiment. sixteen pigeons were infested experimentally and were divided into 4 grou...

A nonlinear analysis of a mechanical model for biological pattern formation, SIAM J. pattern selection in a mechanical model for morphogenesis, Mathematical modelling of the generation and onset of spatial patterns in the early stages of embryonic development — reaction-diffusion equations, chemotaxis equations, mechanochemical force balance equations. (1988): the communication between differen...

We reported a case of a breast cancer's skin metastases in a patient that had sustained 3 lines of chemotherapy. At first she received surgical treatment with Madden's mastectomy with dissection of axillary limphnodes and positioning of an expander. After that she underwent to chemo- and radiotherapy. The schedules we performed were: FEC, TC,Vinorelbine and Capecitabine. Only after the FEC ther...

Background: Human fibroblasts are the part of the dermis that secrete extracellular matrix for the purpose of tissue repair. Culturing fibroblasts, which leads to formation of a monolayer of these cells, is used for treating various conditions including thermal burns and other skin defects such as diabetic and varicose vein leg ulcers. Therefore, we aimed at developing a fibroblast bank to acco...

Skin, the largest organ of the human body, is organized into an elaborate layered structure consisting mainly of the outermost epidermis and the underlying dermis. A subcutaneous adipose-storing hypodermis layer and various appendages such as hair follicles, sweat glands, sebaceous glands, nerves, lymphatics, and blood vessels are also present in the skin. These multiple components of the skin ...

Dermatofibrosarcoma protuberans (DFSP) is very rare tumor of dermis layer of skin with the incidence of only 1 case per million per year. DFSP rarely leads to a metastasis (Less than 5% have metastasis), but DFSP can recur locally. We publish a rare case of a recurrent dermatofibrosarcoma protuberans and its management with radical excision and interval skin grafting.