friction-stir welding process is a novel method of solid state welding, which produces heat due to friction between the pin, the shoulder and the workpiece. this heat causes a paste area. shoulder pressure and pin spin cause edges integration and lead to welding. in this study, firstly, the feasibility of welding of steel sheet (en10130) with a thickness of 1.5mm has been tested by 58 experimen...

The aim of this work was to develop a pulsatile release system with metoprolol for chronotherapeutical use by coating swellable mini-tablets with Eudragit RS. To study the influence of the formulation factors (amount of coating polymer, plasticizer percentage in film coating and swelling agent percentage in mini-tablets), a Box-Behnken design of experiment (DoE) was used. To evaluate the influe...

Background Process optimization deals with various parameters and statistical methods to guarantee consistent cell grow than product quality. Even if high throughput systems can handle these parameter combinations in parallel experiments, the heuristic restriction of boundaries can result in stepwise iterations with many experiments. This can make the way from process development to process est...

The results presented are related to the prediction of the specific grinding force components. The main problems associated with the prediction capability of empirical models developed using the design of experiment (DOE) method are given. In this study an approach suggesting the combination of DOE method and artificial neural network (ANN) is developed. The inputs of the developed ANNs were se...

this paper describes a Design Of Experiments (DOE) based method used in computer-aided design to simulate the impact of process variations on circuit performances. The method is based on a DOE approach using simple first and second order polynomial models with multiple experiment maps. It is a technology & circuit-independent method which allows circuit designers to perform statistical analysis...

Reactive ion etching of aluminum (Al) had been carried out with BCl3/Cl2, and process optimization was performed using statistical process modeling technique. I-optimal design was employed to set up the etch experiment with operating parameters, namely, gas composition, RF power, and chamber pressure. Analysis has been performed on etch rate, selectivity, and profile, individually, and the proc...