Introduction: Doxorubicin is one of the chemotherapy drugs that have harmful effects on blood hematology. Blood hematological diseases are caused by its adverse and anticancer properties. The antioxidant properties several plants been reported to be closely related reduced toxicity in Andaliman (Zanthoxylum acanthopodium) ethanolic extract (AEE) thought reduce doxorubicin due secondary metaboli...

Background: Many men in the world are infertile at reproductive age. One of causes male infertility is side effects chemotherapy drugs. Doxorubicin (DOX) a tetracycline used that has been shown to have adverse on testicular tissue. Objectives: The simultaneous effect high-intensity aerobic exercise and crocin (Cr) consumption doxorubicin-induced tissue not studied. Therefore, aim this study was...

objective: doxorubicin (dox) is a broad spectrum chemotherapeutic agent used in the treatment of several malignancies. the use of dox in clinical chemotherapy has been restricted due to its diverse toxicities, including reproductive toxicity. crataegus monogyna (c. monogyna) is one of the oldest medicinal plants that have been shown to be cytoprotective because of scavenging free radicals. the ...

The comparative pharmacokinetics of free doxorubicin and doxorubicin entrapped in cardiolipin liposomes was evaluated in rats at a dose of 6 mg/kg i.v. Doxorubicin was entrapped in cardiolipin liposomes by using 11.2 mumol of drug, 5.6 mumol of cardiolipin, 28.5 mumol of phosphatidylcholine, 19.5 mumol of cholesterol, and 11.1 mumol of stearylamine. The peak plasma concentration with free doxor...

Background: Doxorubicin (DOX)-induced cardiotoxicity appears to be a growing concern for extensive use in acute lymphoblastic leukemia (ALL). The new combination treatment strategies, therefore might be an effective way of decreasing its side effects as well as improving efficacy. AMG232 (KRT-232) is a potential MDM-2 inhibitor, increasing available p53 through disturbing p53-MDM-2 interaction....

Background: Doxorubicin is an anthracyclin antibiotic that is considered as one of the most effective antitumor agents. The clinical use of doxorubicin soon proved to be hampered by such serious problems as hepatotoxicity and most notably cardiomyopathy. Objectives: The current study aims at evaluating the efficiency of carvedilol as an adjuvant therapy with doxorubicin to protect against doxor...