here we report a novel approach for preparation of a 6-day transdermal drug delivery system (tdds) as treatment for mild to moderate alzheimer’s disease. the spray drying method was used to prepare microparticles containing the anti-alzheimer drug. the content of the drug was determined by high performance liquid chromatography (hplc) method. the morphology and size range of the microparticles ...

Robotics can play a key role when dealing with environments that are inaccessible or hazardous for humans including ship hulls, bridge installations, oil rigs, and first reponse scenarios. Due to irregular terrain, wheeled vehicles are ineffective at traversing the necessary terrain. Legged systems are a salient solution. However, legged systems require special considerations regarding workspac...

This paper presents a vision system for tracking a 3D articulated human model from the observation of isolated features from multiple viewpoints. A generic model is instantiated by estimating invariant elements (limb lengths) during tracking. The model is used as feedback both in the estimation module for filtering and in the segmentation module where it predicts the feature’s position and size...

Robotic vehicles are driving at highway speeds using computer vision and other methods to detect the vehicle’s position on the roadway. Several factors affect system performance and stability. In this paper a simple vehicle and path following model is developed. The effect of vehicle understeer, control delay, and other control parameters is investigated and their effect on stability is present...

Objective(s): The aim of present research was to develop matrix-mini-tablets of lornoxicam filled in capsule for targeting early morning peak symptoms of rheumatoid arthritis. Materials and Methods:Matrix-mini-tablets of lornoxicam were prepared by direct compression method using microsomal enzyme dependent and pH-sensitive polymers which were further filled into an empty HPMC capsule. To asses...

We interpret economic MPC as a scheme that trades off economic performance and stability. We use this notion to design an economic MPC controller that exploits the inherent robustness of a stable auxiliary MPC controller to enhance economic performance. Specifically, we incorporate a flexible stabilizing constraint to the economic MPC formulation that preserves stability of the auxiliary contro...

BACKGROUND The stability of protein drugs remains one of the key hurdles to their success in the market. The aim of the present study was to design a novel nanoemulsion drug-delivery system (NEDDS) that would encapsulate a standard-model protein drug--bovine serum albumin (BSA)--to improve drug stability. METHODS The BSA NEDDS was prepared using a phase-inversion method and pseudoternary phas...

OBJECTIVES To describe (a) Food and Drug Administration (FDA) regulations and guidelines issued by several professional organizations to ensure appropriate storage, handling, and distribution of temperature-controlled prescription drugs from manufacturer to wholesaler to pharmacy to patients; (b) pharmacy business practices that ensure the dispensing of high-quality temperature-controlled drug ...