نتایج جستجو برای: epigenetic barrier for cloning

تعداد نتایج: 10427260  

اترک, حسین,

Human cloning is one of the most controversial issues in ethics. This paper, with analytic-descriptive method, deals with Kant;aposs principle of ends and permission or prohibition of human cloning from its point of view. According to Kant;aposs principle of ends, any action in which humanity is taken as a means, not as an end, is prohibited. There are different interpretations of taking humani...

ژورنال: حقوق پزشکی 2009

Human Cloning phenomenon that is accounted as one of the challenges of the present century is concentrated by legal community of most of the countries. One of the prior countries that reacted against this new phenomenon and took actions in legalization is America. Considering this country’s legal system, in the present article it is tried to explain legal condition of human Cloning in the...

2014
S. S. Ashwin Masaki Sasai

Reprogramming is a process of transforming differentiated cells into pluripotent stem cells by inducing specific modifying factors in the cells. Reprogramming is a non-equilibrium process involving a collaboration at levels separated by orders of magnitude in time scale, namely transcription factor binding/unbinding, protein synthesis/degradation, and epigenetic histone modification. We propose...

2013
Weihua Xu Zicong Li Bo Yu Xiaoyan He Junsong Shi Rong Zhou Dewu Liu Zhenfang Wu

Somatic cell nuclear transfer (SCNT) in mammalian cloning currently remains inefficient. Incomplete or erroneous epigenetic reprogramming of specialized donor somatic nuclear and resulting aberrant gene expression during development of cloned embryos is commonly believed as the main reason that causes the low efficiency of SCNT. Use of small molecular reprogramming modifiers to assist the somat...

شکیبا, الهام, مجد, احمد, موحدی, منیره, هدایتی, مهدی,

Thyroid cancer is one of the most common endocrine malignancies and in the last two decades the number of involved people in the world has been increased. Thyroid cancer in Iran is the seventh most common cancer in women and 14th in men. In recent years many achievements regarding to molecular pathogenic factors such as the substantial role of signaling pathways and molecular abnormalities have...

Both genetic and epigenetic changes are effective in cancer incidence and development. . .Epigenetic processes are alternations of DNA and histones conformations, chromatin remodeling, DNA methylation, post-translational modifications of histones and microRNAs patterns which are associated with genes expression or inhibition of them in cells. Some of reversible epigenetic changes such as DNA an...

Journal: :Cell stem cell 2013
Sayaka Wakayama Takashi Kohda Haruko Obokata Mikiko Tokoro Chong Li Yukari Terashita Eiji Mizutani Van Thuan Nguyen Satoshi Kishigami Fumitoshi Ishino Teruhiko Wakayama

Previous studies of serial cloning in animals showed a decrease in efficiency over repeated iterations and a failure in all species after a few generations. This limitation led to the suggestion that repeated recloning might be inherently impossible because of the accumulation of lethal genetic or epigenetic abnormalities. However, we have now succeeded in carrying out repeated recloning in the...

ژورنال: Iranian Biomedical Journal 2018
Farivar, Shirin, Shaabanpour Aghamaleki, Fateme,

The pathogenesis of systemic lupus erythematosus (SLE) is influenced by both genetic factors and epigenetic modifications; the latter is a result of exposure to various environmental factors. Epigenetic modifications affect gene expression and alter cellular functions without modifying the genomic sequences. CpG-DNA methylation, histone modifications, and miRNAs are the main epigenetic factors ...

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